在伯基特淋巴瘤相关易位中，8号染色体上两个细胞遗传学可区分的断点的交替参与。

Alternative involvement of two cytogenetically distinguishable breakpoints on chromosome 8 in Burkitt's lymphoma associated translocations.

作者信息

Manolov G, Manolova Y, Klein G, Lenoir G, Levan A

出版信息

Cancer Genet Cytogenet. 1986 Feb 1;20(1-2):95-9. doi: 10.1016/0165-4608(86)90111-1.

Abstract

The chromosomes of 16 Burkitt's lymphoma (BL) derived cell lines were submitted to high-resolution G-band analysis. They included seven lines with t(8;14), three with t(2;8), and four with t(8;22). The translocation breakpoint in chromosome #14 was located in 14q32.3, in chromosome #2 in 2p11.1, and in chromosome #22 in 22q12.12. In chromosome #8, the translocation breakpoint was located in two cytogenetically distinct subbands: 8q24.1 in cell lines with t(8;14) and t(2;8) and 8q24.22 in cell lines with t(8;22). In the light of recent molecular findings, these results indicate that the distance between the c-myc gene, located in 8q24, and the Ig sequences might be much larger in BL lines with t(8;22) than in those with t(2;8).

摘要

对16个源自伯基特淋巴瘤（BL）的细胞系的染色体进行了高分辨率G带分析。其中包括7个携带t(8;14)的细胞系、3个携带t(2;8)的细胞系和4个携带t(8;22)的细胞系。14号染色体的易位断点位于14q32.3，2号染色体的易位断点位于2p11.1，22号染色体的易位断点位于22q12.12。在8号染色体上，易位断点位于两个细胞遗传学上不同的亚带：携带t(8;14)和t(2;8)的细胞系中位于8q24.1，携带t(8;22)的细胞系中位于8q24.22。根据最近的分子研究结果，这些结果表明，位于8q24的c-myc基因与Ig序列之间的距离在携带t(8;22)的BL细胞系中可能比携带t(2;8)的细胞系中要大得多。