Bernheim A, Berger R, Lenoir G
Cancer Genet Cytogenet. 1981 Jun;3(4):307-15. doi: 10.1016/0165-4608(81)90039-x.
Cytogenetic studies on ten African Epstein-Barr virus (EBV) positive Burkitt's lymphoma (BL) cell lines were performed. The usual translocation t(8;14) (q24;q32) was found in five of them, a deletion del(8) (q24 leads to qter) in another one, while four variants were observed, two of these having a t(2;8) (p12;q24) translocation and two a t(8;22) (q24;q11) translocation. Other chromosome abnormalities were seen in seven of the cell lines, but these varied from one cell line to another. Thus, variant translocations, such as we describe here, are found in endemic BL cases. Two of these variants are identical to those previously identified in BL from nonendemic areas. The common chromosome abnormality of these BL cell lines was a rearrangement of the 8q24 band. The role of this constant cytogenetic change remains to be elucidated.
对十个非洲爱泼斯坦-巴尔病毒（EBV）阳性的伯基特淋巴瘤（BL）细胞系进行了细胞遗传学研究。其中五个细胞系发现了常见的易位t(8;14)(q24;q32)，另一个细胞系发现了缺失del(8)(q24至qter)，同时观察到四个变体，其中两个具有t(2;8)(p12;q24)易位，两个具有t(8;22)(q24;q11)易位。在七个细胞系中还观察到其他染色体异常，但这些异常在不同细胞系之间有所不同。因此，在地方性BL病例中发现了我们在此描述的变体易位。其中两个变体与先前在非地方性地区的BL中鉴定出的变体相同。这些BL细胞系常见的染色体异常是8q24带的重排。这种持续的细胞遗传学变化的作用仍有待阐明。
