Barbieri D, Spanedda R, Castoldi G L
Cancer Genet Cytogenet. 1986 Feb 15;20(3-4):287-92. doi: 10.1016/0165-4608(86)90085-3.
Cytogenetic studies were performed on the cells of bone marrow, peripheral blood, and skin tumor biopsies from a patient with mycosis fungoides at an early stage. Chromosome abnormalities were detected in 100% of the cells harvested from the cutaneous specimen, whereas the cells of the bone marrow and blood were karyotypically normal. Three related clones, showing increasing cytogenetic complexity, were found. Chromosome #12 was abnormal in all metaphases, and an abnormal 14q chromosome was present in a minority of cells belonging to the most complex emerging subclone. These data, along with the findings of important signs of chromosome imbalance, suggest a polyphasic evolution of this chronic T lymphoproliferative disease.
对一名早期蕈样肉芽肿患者的骨髓、外周血和皮肤肿瘤活检组织的细胞进行了细胞遗传学研究。从皮肤标本中采集的细胞100%检测到染色体异常，而骨髓和血液细胞的核型正常。发现了三个相关克隆，其细胞遗传学复杂性不断增加。在所有中期相中12号染色体均异常，在属于最复杂的新兴亚克隆的少数细胞中存在一条异常的14q染色体。这些数据以及染色体失衡重要迹象的发现，提示了这种慢性T淋巴细胞增殖性疾病的多阶段演变。
