Ohyashiki K, Yoshida M A, Ohyashiki J, Block A W, Dabski K, Sandberg A A
Cancer Genet Cytogenet. 1985 Dec;18(4):295-302. doi: 10.1016/0165-4608(85)90150-5.
A 32-year-old white male was diagnosed as having mycosis fungoides in 1976; bone marrow biopsy and aspiration in August 1984 revealed infiltration with neoplastic cells. Cytogenetic analysis of the cells from the bone marrow specimen showed that 48 of 50 metaphases contained an extra Y chromosome (i.e., 47,XYY). The remaining two cells were hypotetraploid and hyperpentaploid, respectively, with a common marker derived from chromosome #2. The metaphases obtained by PHA stimulation of peripheral blood cells showed a 47,XYY pattern. An interleukin 2 (IL-2) dependent T-cell line was established from the patient's blood mononuclear cells; all metaphases of this line had an extra Y chromosome. Thus, this case is one of a mycosis fungoides developing in an XYY male.
一名32岁的白人男性于1976年被诊断为蕈样肉芽肿；1984年8月的骨髓活检和穿刺显示有肿瘤细胞浸润。对骨髓标本中的细胞进行细胞遗传学分析发现，50个中期细胞中有48个含有一条额外的Y染色体（即47,XYY）。其余两个细胞分别为亚四倍体和超五倍体，有一条来自2号染色体的共同标记染色体。通过PHA刺激外周血细胞获得的中期细胞显示为47,XYY核型。从患者的血液单核细胞中建立了一株白细胞介素2（IL-2）依赖的T细胞系；该细胞系的所有中期细胞都有一条额外的Y染色体。因此，该病例是一名XYY男性发生蕈样肉芽肿的病例之一。
