van Vloten W A, Pet E A, Geraedts J P
Br J Dermatol. 1980 May;102(5):507-13. doi: 10.1111/j.1365-2133.1980.tb07647.x.
G-banded chromosome analysis was performed on peripheral blood lymphocytes after phytohaemagglutinin stimulation from sixteen patients with mycosis fungoides. A number of chromosome abnormalities were observed in a low proportion of blood lymphocytes in seven patients in later stages of the disease. In four patients similar marker chromosomes in multiple copies were present, some of them without a clearly visible centromere. We conclude that a correlation exists between the presence of chromosome abnormalities in circulating blood lymphocytes and the course of the disease.
对16例蕈样肉芽肿患者经植物血凝素刺激后的外周血淋巴细胞进行了G带染色体分析。在疾病后期的7例患者中，低比例的血液淋巴细胞中观察到一些染色体异常。4例患者存在多个拷贝的相似标记染色体，其中一些没有清晰可见的着丝粒。我们得出结论，循环血液淋巴细胞中染色体异常的存在与疾病进程之间存在相关性。
