亚种中费雷二醇和铁三醇的新酯类：表征与抗增殖活性

New Esters of Ferrediol and Sideritriol in subsp. : Characterization and Antiproliferative Activity.

作者信息

Dimaki Virginia D, Stamopoulou Efstathia, Manou Dimitra, Theocharis Achilleas D, Fousteris Manolis A, Lamari Fotini N

机构信息

Department of Pharmacy, University of Patras, Patras 26504, Greece.

Department of Chemistry, University of Patras, Patras 26504, Greece.

出版信息

ACS Omega. 2024 Oct 4;9(41):42253-42260. doi: 10.1021/acsomega.4c04628. eCollection 2024 Oct 15.

DOI:10.1021/acsomega.4c04628

PMID:39431076

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11483387/

Abstract

17-Isovalerate esters of ferrediol and sideritriol (compounds and ) and 17-(2-methylbutyrate) ferrediol (compound ), which have not been earlier described, were isolated along with five known -15-kaurene diterpenes (siderol, sideridiol, sideroxol, eubotriol, and -candicandiol), one -beyerene (flavovirol), and one phytosterol (β-sitosterol) from the aerial parts of subsp. (Boiss. & Heldr.) Baden that is a mountain tea species endemic to Northern Peloponnese in Greece. Compounds - exhibited weak antiproliferative activity against triple-negative MDA-MB-231 and Hs578T breast cancer cells. In MCF-7 breast cancer cells, compounds , , siderol, and sideridiol were equipotent to 5-fluorouracil (moderate antiproliferative activity).

摘要

从希腊伯罗奔尼撒半岛北部特有的山茶物种亚种（Boiss. & Heldr.）Baden的地上部分分离出了此前未被描述过的铁二醇和三羟基铁三醇的17 - 异戊酸酯（化合物和）以及17 -（2 - 甲基丁酸酯）铁二醇（化合物），同时还分离出了五种已知的 - 15 - 贝壳杉烯二萜（铁醇、铁二醇、铁氧醇、真三醇和 - 坎迪二醇）、一种 - 贝叶烯（黄维罗醇）和一种植物甾醇（β - 谷甾醇）。化合物 - 对三阴性MDA - MB - 231和Hs578T乳腺癌细胞表现出微弱的抗增殖活性。在MCF - 7乳腺癌细胞中，化合物、、铁醇和铁二醇的活性与5 - 氟尿嘧啶相当（中等抗增殖活性）。