Laboratoire de Chimie-Toxicologie Analytique et Cellulaire (C-TAC) UMR CNRS 8038 CiTCoM Université Paris-Descartes, 4, avenue de l'Observatoire, 75006 Paris, France.
Laboratoires Clarins, 5 rue Ampère, 95300 Pontoise, France.
Molecules. 2020 Jan 29;25(3):589. doi: 10.3390/molecules25030589.
This paper reports the isolation and structural characterization of four new -kaurane derivatives from the Lamiaceae plant . Planar structures and relative configurations were determined using both mass spectrometry and nuclear magnetic resonance (1D and 2D). Absolute configurations were determined by comparing experimental and theoretical electronic circular dichroism spectra. The cytotoxic and microbial activities of all new compounds were tested. Compounds that were non-cytotoxic were further evaluated for anti-inflammatory activity.
本文报道了从唇形科植物中分离得到的四个新贝壳杉烷衍生物，并对其结构进行了鉴定。通过质谱和核磁共振（一维和二维）确定了它们的平面结构和相对构型。通过比较实验和理论电子圆二色谱确定了它们的绝对构型。测试了所有新化合物的细胞毒性和微生物活性。对非细胞毒性的化合物进一步评估了其抗炎活性。
