Vocational School, Izmir Democracy University, Izmir, Turkey.
Department of Science Education, Necatibey Faculty of Education, Balıkesir University, Balıkesir, Turkey.
Pharm Biol. 2023 Dec;61(1):1484-1511. doi: 10.1080/13880209.2023.2280253. Epub 2023 Nov 22.
The genus L. (Lamiaceae) is represented by 46 species in Turkey with an 79% endemism ratio, 42 of 46 belonging to the section Empodoclia.
In this review article, species growing in Turkey have been evaluated for phytochemical constituents and biological activities.
The data for the isolates, components and extracts of the Anatolian species and their bioactivity studies were retrieved from the main databases WoS, Scopus and PubMed from 1975 until 31 December 2022.
In this review article, terpenoids, flavonoids, phenolics and other secondary metabolites isolated from Turkish species were reported. Anatolian species, which primarily consist of monoterpenes and sesquiterpenes, were studied in detail. plants are represented by 46 species in Turkey, and 25 of them were investigated for their diterpenoids through isolation or LC-MS studies. Most of the diterpenoids of Turkish species have -kaurene skeleton, among them linearol, siderol, 7-candicandiol and sideridiol were found to be the main compounds. Exceptionally, labdane, pimarane and beyerene diterpenoids were only found in a few species. For phenolics and flavonoids, only 12 species were investigated until now, and they were found to be rich in phenylethanoid glycosides and flavonoid glycosides. In terms of activity, most of the species were tested for antioxidant activity, followed by antimicrobial and anti-ulcer/anti-inflammatory activities. Their cytotoxic, enzyme inhibitory, antinociceptive and antistress activities were less frequently studied.
species should be considered promising therapeutic agents in the treatment of upper respiratory tract and ulcer/inflammatory diseases.
土耳其的唇形科（Lamiaceae）属有 46 种，特有率为 79%，其中 42 种属于 Empodoclia 组。
本文综述了土耳其产唇形科植物的化学成分和生物活性。
从 WoS、Scopus 和 PubMed 等主要数据库中检索了 1975 年至 2022 年 12 月 31 日期间土耳其产的唇形科植物的分离物、成分和提取物及其生物活性研究的数据。
本文综述了从土耳其产唇形科植物中分离得到的萜类、黄酮类、酚类等次生代谢产物。对以单萜和倍半萜为主的土耳其产唇形科植物进行了详细研究。土耳其有 46 种唇形科植物，其中 25 种通过分离或 LC-MS 研究对其二萜进行了研究。土耳其产唇形科植物的二萜大多具有 -kaurene 骨架，其中 linearol、siderol、7-candicandiol 和 sideridiol 被认为是主要化合物。例外的是，labdane、pimarane 和 beyerene 二萜仅在少数几种植物中发现。关于酚类和黄酮类，目前仅对 12 种植物进行了研究，它们富含苯乙醇苷和黄酮苷。就活性而言，大多数植物都进行了抗氧化活性测试，其次是抗菌和抗溃疡/抗炎活性。它们的细胞毒性、酶抑制、镇痛和抗应激活性研究较少。
唇形科植物被认为是治疗上呼吸道和溃疡/炎症疾病的有前途的治疗剂。
