Kumar Barun, Chawla Omna, Nigam Abhimanyu, Singh Pankaj Kumar, Singh Anupam
Department of Cardiology, AIIMS Rishikesh, Uttarakhand, India.
Department of Physiology, Government Medical College, Haridwar, Uttarakhand, India.
Toxicol Rep. 2024 Oct 1;13:101755. doi: 10.1016/j.toxrep.2024.101755. eCollection 2024 Dec.
Cannabis is a psychoactive substance consumed worldwide in the form of smoking, vapors, food additives, or beverages. Delta 9 tetrahydrocannabinol (THC) is a primary component responsible for short and long-term effects on various cognitive and motor functions in a dose-dependent manner. The legal status of cannabis has shifted significantly in recent decades. Some regions maintain strict penalties, but others have legalized them for medicinal use. In India, the use of cannabis in any form is illegal; however, the use of bhang, a cannabis beverage made from leaves, is acceptable due to cultural reasons and thus permitted in some places. We report the case of a 28-year-old male who developed massive anterior wall myocardial infarction after consuming bhang during the Holi festival. He presented with sudden retrosternal chest pain, which was initially ignored till it intensified enough, prompting him to seek emergency medical help approximately 24 hours after symptom onset. Cannabis intoxication impaired attention and information processing, leading to delayed presentation. The patient was managed successfully by timely cardiac intervention. The evolving landscape of cannabis regulations necessitates heightened awareness among health authorities about potential cardiovascular risks associated with its consumption, particularly in forms like Bhang, where concentrations are unregulated and variable.
大麻是一种精神活性物质，在全球范围内以吸烟、吸食蒸汽、食品添加剂或饮料的形式被使用。δ9四氢大麻酚（THC）是一种主要成分，以剂量依赖的方式对各种认知和运动功能产生短期和长期影响。近几十年来，大麻的法律地位发生了显著变化。一些地区维持严格的处罚，但其他一些地区已将其用于医疗用途合法化。在印度，任何形式的大麻使用都是非法的；然而，由于文化原因，由叶子制成的大麻饮料“邦”的使用是可以接受的，因此在一些地方是允许的。我们报告了一例28岁男性在胡里节期间饮用“邦”后发生大面积前壁心肌梗死的病例。他出现突发胸骨后胸痛，最初被忽视，直到疼痛加剧，促使他在症状出现后约24小时寻求紧急医疗帮助。大麻中毒损害了注意力和信息处理能力，导致就诊延迟。通过及时的心脏干预，患者得到了成功治疗。大麻法规的不断变化要求卫生当局提高对其消费相关潜在心血管风险的认识，特别是在像“邦”这样浓度不受监管且变化不定的形式中。
