Sharghi Sima, Stoll Kevin, Ning Wei
Department of Biostatistics and Computational Biology, University of Rochester, New York, USA.
Welltower Inc, Ohio, USA.
Stat Pap (Berl). 2024 Sep;65(7):4079-4120. doi: 10.1007/s00362-024-01553-1. Epub 2024 Apr 16.
In this paper, we advance the application of empirical likelihood (EL) for missing response problems. Inspired by remedies for the shortcomings of EL for parameter hypothesis testing, we modify the EL approach used for statistical inference on the mean response when the response is subject to missing behavior. We propose consistent mean estimators, and associated confidence intervals. We extend the approach to estimate the average treatment effect in causal inference settings. We detail the analogous estimators for average treatment effect, prove their consistency, and example their use in estimating the average effect of smoking on renal function of the patients with atherosclerotic renal-artery stenosis and elevated blood pressure, chronic kidney disease, or both. Our proposed estimators outperform the historical mean estimators under missing responses and causal inference settings in terms of simulated relative RMSE and coverage probability on average.
在本文中,我们推进了经验似然(EL)在缺失响应问题中的应用。受针对EL在参数假设检验方面缺点的补救措施启发,我们修改了用于对响应存在缺失行为时的均值响应进行统计推断的EL方法。我们提出了一致的均值估计量以及相关的置信区间。我们将该方法扩展到因果推断设置中以估计平均治疗效果。我们详细阐述了平均治疗效果的类似估计量,证明了它们的一致性,并举例说明了它们在估计吸烟对患有动脉粥样硬化性肾动脉狭窄和高血压、慢性肾病或两者皆有的患者肾功能的平均影响中的应用。在缺失响应和因果推断设置下,就模拟的相对均方根误差(RMSE)和平均覆盖概率而言,我们提出的估计量优于历史均值估计量。