Skvor J, Trnka L
Scand J Respir Dis. 1979 Aug;60(4):161-7.
Cell immunity profiles were determined in 46 patients with previously untreated pulmonary tuberculosis, confirmed bacteriologically, and in 21 blood donors. Evaluations were made of T-lymphocytes, blastic transformation of lymphocytes after stimulation with phytohaemagglutinin or tuberculoprotein, and migration inhibition of blood leukocytes stimulated by tuberculo-protein. The average proportion of T-lymphocytes in the peripheral blood was significantly diminished in the group of tuberculous patients, and the intensity of the decline correlated both with age and extent of the disease. Similarly, migration of leukocytes in tuberculous patients was, in the presence of tuberculoprotein, markedly inhibited. The inhibition was correlated to the extent of the disease, expressed as the number of bacilli excreted. It can be concluded that, despite the depression of immunocompetent cells, active daughter clones under the influence of a specific antigen are capable of producing a factor conditioning migration inhibition.
对46例经细菌学确诊的初治肺结核患者和21名献血者进行了细胞免疫谱测定。评估了T淋巴细胞、植物血凝素或结核菌素刺激后淋巴细胞的母细胞转化，以及结核菌素刺激的血液白细胞的迁移抑制。肺结核患者外周血中T淋巴细胞的平均比例显著降低，且下降强度与年龄和疾病程度均相关。同样，在结核菌素存在的情况下，肺结核患者白细胞的迁移受到明显抑制。这种抑制与疾病程度相关，以排出的杆菌数量表示。可以得出结论，尽管免疫活性细胞受到抑制，但在特定抗原的影响下，活跃的子代克隆能够产生一种调节迁移抑制的因子。
