Emory University, Atlanta, GA, USA.
Emory University Hospital, Atlanta, GA, USA.
J Investig Med High Impact Case Rep. 2024 Jan-Dec;12:23247096241292230. doi: 10.1177/23247096241292230.
Cryptococcal species are the most common fungal pathogens to cause meningitis worldwide. The majority of cases are caused by and occur in immunocompromised hosts, while causes most fungal meningitis in immunocompetent hosts. To date, non-, non- species of remain rare causes of human disease, and their clinical courses and preferred treatment regimens remain poorly characterized. We present the case of an otherwise immunocompetent woman with subacute meningoencephalitis diagnosed with formerly meningitis, who, despite successful fungal eradication, developed hydrocephalus. To our knowledge, this represents the first case of meningitis in an immunocompetent host leading to hydrocephalus, illustrating the diagnostic and therapeutic challenges that remain for atypical fungal meningitis.
隐球菌属是全球最常见的引起真菌性脑膜炎的病原体。大多数病例由 引起，发生于免疫功能低下的宿主中，而 在免疫功能正常的宿主中引起大多数真菌性脑膜炎。迄今为止，非-，非- 种 仍然是人类疾病的罕见病因，其临床病程和首选治疗方案仍未得到充分描述。我们报告了一例免疫功能正常的妇女亚急性脑膜脑炎，诊断为以前的 脑膜炎，尽管真菌被成功根除，但仍发生了脑积水。据我们所知，这是首例免疫功能正常的宿主中由 引起的脑膜炎导致脑积水的病例，说明了非典型真菌性脑膜炎仍然存在诊断和治疗挑战。
