Department of Gynaecology, Tangshan Hongci Hospital, Tangshan, Hebei, China.
Department of Oncology Surgery, Tangshan People's Hospital, Tangshan, Hebei, China.
PLoS One. 2024 Oct 21;19(10):e0311492. doi: 10.1371/journal.pone.0311492. eCollection 2024.
The effects of metabolic obesity (MO) phenotypes status and their dynamic changes on urologic cancer (UC) is ignored. We aimed to investigate the association between metabolic syndrome (MetS) and MO status at baseline, their dynamic changes and UC risk.
This paper studied 97,897 subjects who were free of cancers at baseline (2006-2007). Individuals were classified into four MO phenotypes by MetS and obesity at baseline. Transitions in MetS and MO status from 2006-2007 to 2008-2009 were considered. The hazard ratios (HRs) and 95% confidence intervals (CIs) for UC were assessed by multifactorial Cox proportional risk regression models. The main limitations of this study are as follows: the ratio of men to women in the cohort is unbalanced; the impacts of MetS and MO on each cancer type (kidney cancer, prostate cancer, bladder cancer) have not been analyzed separately; the transition intervals of MetS and MO phenotypes are relatively short.
From baseline (2006-2007) survey to December 31, 2020, during a median follow-up of 14.02 years, 554 cases of UC were diagnosed. Participants with MetS [HRs (95% CI) = 1.26 (1.06-1.49)] and metabolically unhealthy obesity (MUO) [HRs (95% CI) = 1.49 (1.17-1.89)] had significantly higher risk of UC than those with non-MetS and metabolically healthy normal weight (MHN). Transitions in MetS and MO phenotypes over time were studied. Compared with non-MetS to non-MetS, the risks for UC in MetS to MetS [HRs (95% CI) = 1.45 (1.11-1.88)] was increased. Compared with MHN to MHN, both MUO to metabolically healthy obesity (MHO) [HRs (95% CI) = 2.65 (1.43-4.92)] and MUO to MUO [HRs (95% CI) = 1.60 (1.06-2.42)] had significantly higher UC risk.
MetS and MUO increased the UC risk at baseline. Transitions of MetS to MetS, MUO to MUO and even MUO to MHO over time significantly increased the risk of UC development.
代谢性肥胖（MO）表型状态及其动态变化对泌尿系统癌症（UC）的影响尚未得到充分认识。本研究旨在探讨基线时代谢综合征（MetS）和 MO 状态及其动态变化与 UC 风险之间的关联。
本研究纳入了 97897 名基线时无癌症的研究对象（2006-2007 年）。根据基线时的 MetS 和肥胖情况，个体被分为四种 MO 表型。考虑了 2006-2007 年至 2008-2009 年期间 MetS 和 MO 状态的变化。采用多因素 Cox 比例风险回归模型评估 UC 的风险比（HRs）和 95%置信区间（CIs）。本研究的主要局限性如下：队列中男女比例不平衡；MetS 和 MO 对每种癌症类型（肾癌、前列腺癌、膀胱癌）的影响尚未单独分析；MetS 和 MO 表型的转变间隔相对较短。
从基线（2006-2007 年）调查到 2020 年 12 月 31 日，中位随访 14.02 年期间，共诊断出 554 例 UC。与非 MetS 相比，患有 MetS [HRs（95%CI）=1.26（1.06-1.49）]和代谢不健康肥胖（MUO）[HRs（95%CI）=1.49（1.17-1.89）]的个体患 UC 的风险显著增加。还研究了随时间推移 MetS 和 MO 表型的变化。与非 MetS 到非 MetS 相比，MetS 到 MetS 的 UC 风险增加[HRs（95%CI）=1.45（1.11-1.88）]。与 MHN 到 MHN 相比，MUO 到 MHO [HRs（95%CI）=2.65（1.43-4.92）]和 MUO 到 MUO [HRs（95%CI）=1.60（1.06-2.42）]的 UC 风险显著增加。
MetS 和 MUO 增加了基线时的 UC 风险。MetS 向 MetS、MUO 向 MUO 甚至 MUO 向 MHO 的转变随时间显著增加了 UC 发展的风险。
