Harrache Amira, Saker Kahina, Mokdad Bouchra, Generenaz Laurence, Saade Carla, Pons Sylvie, Fassier Jean-Baptiste, Bal Antonin, Trabaud Mary-Anne, Rabilloud Muriel, Abichou-Klich Amna, Trouillet-Assant Sophie
Biostatistics Department, Hospices Civils de Lyon, Lyon France. CNRS, UMR 5558, University of Lyon, Biometrics and Evolutionary Biology Laboratory, Biostatistics-Health Team, 69100 Villeurbanne, France.
Joint Research Unit Hospices Civils of Lyon-bioMérieux, Lyon Sud Hospital, Hospices Civils de Lyon, 69310 Pierre-Bénite, France.
Vaccine. 2024 Dec 2;42(26):126464. doi: 10.1016/j.vaccine.2024.126464. Epub 2024 Oct 20.
Identifying parameters influencing SARS-CoV-2 antibody dynamics post infection or vaccination is crucial for refining vaccination strategies. In a longitudinal analysis of 1340 samples from 375 healthcare workers, we characterized peak serological response and IgG half-life. Peak antibody titers post 2 vaccine doses were ∼ 20 times higher than natural infection; conversely, infected individuals had extended antibody half-life. Clinical and demographical factors such as BMI, age and smoking shaped peak response without affecting anti-RBD IgG half-life. A third mRNA vaccine dose increased peak antibody titers and prolonged half-life compared to the second dose. These findings underscore the diverse kinetics of SARS-CoV-2 antibody responses, which is influenced by immunization type/number and clinical factors.
确定感染或接种疫苗后影响SARS-CoV-2抗体动态变化的参数对于完善疫苗接种策略至关重要。在对375名医护人员的1340份样本进行的纵向分析中，我们对血清学反应峰值和IgG半衰期进行了特征描述。两剂疫苗接种后的抗体滴度峰值比自然感染高约20倍；相反，感染者的抗体半衰期延长。体重指数、年龄和吸烟等临床和人口统计学因素影响抗体反应峰值，但不影响抗RBD IgG半衰期。与第二剂相比，第三剂mRNA疫苗增加了抗体滴度峰值并延长了半衰期。这些发现强调了SARS-CoV-2抗体反应的不同动力学，这受到免疫类型/次数和临床因素的影响。
