成年雄性大鼠与其他物种的醋酸纤维素电泳血清脂蛋白 - 胆固醇图谱比较。

A comparison of the cellulose acetate electrophoretic serum lipoprotein-cholesterol profile of the adult male rat with other species.

作者信息

Davis J R, Davis A R, Rosenzweig I B

出版信息

Comp Biochem Physiol B. 1986;83(1):37-44. doi: 10.1016/0305-0491(86)90328-7.

Abstract

A comparison was made of the serum lipoprotein-cholesterol profile, obtained by cellulose acetate electrophoresis coupled with an enzymatic stain for total cholesterol, of the adult male rat, mouse, rabbit, dog, monkey and human. Four cholesterol-staining lipoprotein bands were detected in rat serum, while only three cholesterol-staining lipoprotein bands were present in the other species studied. The apparently unique lipoprotein-cholesterol band in the rat was found to electrophoretically migrate in the prealbumin region of rat serum, has been named prealbumin lipoprotein-cholesterol (PAL-C) and was shown to be a high density lipoprotein (HDL). Of the species studied those more susceptible to experimentally induced atherosclerosis had higher low density lipoprotein-cholesterol to HDL-cholesterol ratios compared to those species least susceptible to experimentally induced atherosclerosis.

摘要

对成年雄性大鼠、小鼠、兔子、狗、猴子和人类通过醋酸纤维素电泳结合总胆固醇酶染色获得的血清脂蛋白胆固醇谱进行了比较。在大鼠血清中检测到四条胆固醇染色的脂蛋白带，而在其他研究的物种中仅存在三条胆固醇染色的脂蛋白带。在大鼠中明显独特的脂蛋白胆固醇带被发现在大鼠血清的前白蛋白区域电泳迁移，已被命名为前白蛋白脂蛋白胆固醇（PAL-C），并被证明是一种高密度脂蛋白（HDL）。在所研究的物种中，与那些对实验性诱导动脉粥样硬化最不敏感的物种相比，那些对实验性诱导动脉粥样硬化更敏感的物种具有更高的低密度脂蛋白胆固醇与HDL胆固醇比率。