耳鸣与痴呆风险：一项基于全国人口的病例对照研究。
Tinnitus and dementia risk: a nationwide population-based case-control study.
作者信息
Butt Wesley W W, Wieland Daniel R, Wang Han, Lin Ching-Heng, Wang Jing-Jie, Weng Chien-Hsiang
机构信息
Internal Medicine, University of Pennsylvania Health System, Philadelphia, PA, USA.
Department of Biomedical Engineering, University of Arizona, Tucson, AZ, USA.
出版信息
J Laryngol Otol. 2024 Dec;138(12):1170-1175. doi: 10.1017/S0022215124001130. Epub 2024 Oct 22.
OBJECTIVE
This study aimed to determine if a history of tinnitus is associated with the risk of developing dementia.
METHOD
A nationwide population-based case-control study including all eligible adults in Taiwan.
RESULTS
A total of 15 686 patients were included in the study, with 7843 individuals making up each of the case and control groups. Patients with a history of tinnitus were associated with a statistically significant higher risk of being diagnosed with dementia before reaching 65 years old (50 years ≤ age <65 years) (adjusted odds ratio 2.68, 95 per cent confidence interval (CI) 1.19-6.05, = 0.017). No statistical significance was found among those 65 years and older (adjusted odds ratio 1.17, 95 per cent CI 0.90-1.51, = 0.235).
CONCLUSION
A history of tinnitus was associated with a 168 per cent increased risk of being diagnosed with dementia in those aged 50-65 years old. This association was not significant in those older than 65 years.
目的
本研究旨在确定耳鸣病史是否与患痴呆症的风险相关。
方法
一项基于全国人口的病例对照研究，纳入了台湾所有符合条件的成年人。
结果
本研究共纳入15686名患者，病例组和对照组各有7843人。有耳鸣病史的患者在65岁之前（50岁≤年龄<65岁）被诊断为痴呆症的风险在统计学上显著更高（调整后的优势比为2.68，95%置信区间（CI）为1.19 - 6.05，P = 0.017）。在65岁及以上的人群中未发现统计学意义（调整后的优势比为1.17，95%CI为0.90 - 1.51，P = 0.235）。
结论
耳鸣病史与50 - 65岁人群被诊断为痴呆症的风险增加168%相关。在65岁以上人群中，这种关联不显著。
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