Knowles C O, Johnson T L
Environ Res. 1986 Feb;39(1):172-9. doi: 10.1016/s0013-9351(86)80019-6.
The effects of ten organotins on rat platelet aggregation mechanisms were examined. Bis(tri-n-butyltin)oxide was the most potent inhibitor of both ADP- and collagen-induced aggregation, and it was the only organotin that directly induced aggregation. It also increased the latent period for induction of aggregation by collagen. Triphenyltin hydroxide was a weak inhibitor of both ADP- and collagen-induced aggregation. However, in contrast to bis(tri-n-butyltin)oxide, it decreased the latent period for collagen-induced aggregation. A similar effect also was observed with diphenyltin dichloride, phenyltin trichloride, and cyhexatin. Tri-n-butyltin chloride and tetra-n-butyltin demonstrated specificity in their action since aggregation induced by ADP but not collagen was inhibited. Tri-n-propyltin chloride, trimethyltin chloride, and fenbutatin oxide were without discernible effect on rat platelet aggregation.
研究了十种有机锡对大鼠血小板聚集机制的影响。氧化双（三正丁基锡）是二磷酸腺苷（ADP）和胶原诱导聚集的最有效抑制剂，并且它是唯一直接诱导聚集的有机锡。它还延长了胶原诱导聚集的潜伏期。氢氧化三苯基锡是ADP和胶原诱导聚集的弱抑制剂。然而，与氧化双（三正丁基锡）相反，它缩短了胶原诱导聚集的潜伏期。二氯化二苯基锡、三氯化苯基锡和三环锡也观察到类似的效果。三正丁基氯化锡和四正丁基锡表现出作用特异性，因为它们抑制ADP诱导的聚集而不抑制胶原诱导的聚集。三正丙基氯化锡、三甲基氯化锡和克螨特对大鼠血小板聚集没有明显影响。
