柔嫩艾美耳球虫、毒害艾美耳球虫、堆型艾美耳球虫、巨型艾美耳球虫和布氏艾美耳球虫：尿苷类似物1-(β-D-呋喃核糖基)-2(1H)-吡嗪酮4-氧化物具有强大的抗球虫活性。

Eimeria tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti: potent anticoccidial activity of an uridine analog, 1-(beta-D-ribofuranosyl)-2(1H)-pyrazinone 4-oxide.

作者信息

Kobayashi N, Matsuno T, Hariguchi F, Yamazaki T, Imai K, Onaga H, Ishii T

出版信息

Exp Parasitol. 1986 Feb;61(1):42-7. doi: 10.1016/0014-4894(86)90133-5.

Abstract

The anticoccidial activity of an uridine analog, 1-(beta-D-ribofuranosyl)-2(1H)-pyrazinone 4-oxide (emimycin riboside), against five species of chicken Eimeria was tested individually in battery experiments. With 16 ppm of the compound in feed, marked anticoccidial activity was obtained against Eimeria tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti. The last named species was more drug-sensitive than the others--dietary levels of at least 8 ppm of the drug exhibited good protection and eliminated practically all clinical signs. The battery tests with delayed and restricted medications showed that emimycin riboside affected the development of parasites in first and second generation schizogony of the life cycle of E. tenella.

摘要

在雏鸡笼饲试验中，分别测试了一种尿苷类似物1-(β-D-呋喃核糖基)-2(1H)-吡嗪酮4-氧化物（埃米霉素核糖苷）对五种鸡艾美耳球虫的抗球虫活性。饲料中添加16 ppm该化合物时，对柔嫩艾美耳球虫、毒害艾美耳球虫、堆型艾美耳球虫、巨型艾美耳球虫和布氏艾美耳球虫均有显著抗球虫活性。最后提到的布氏艾美耳球虫比其他几种球虫对药物更敏感——饲料中药物含量至少为8 ppm时可表现出良好的保护作用，并几乎消除所有临床症状。采用延迟给药和限制给药的笼饲试验表明，埃米霉素核糖苷影响柔嫩艾美耳球虫生命周期中第一代和第二代裂殖生殖阶段寄生虫的发育。