Lankisch P G, Otto J, Erkelenz I, Lembcke B
Gastroenterology. 1986 Mar;90(3):617-21. doi: 10.1016/0016-5085(86)91115-7.
Pancreatic calcifications are believed to occur only in advanced stages of exocrine pancreatic insufficiency. This belief has been reevaluated by correlating the results of the secretin-pancreozymin test, fecal fat analysis, and the presence of pancreatic calcifications on plain abdominal x-rays in 79 patients with chronic pancreatitis. Exocrine pancreatic insufficiency was classified as slight, moderate, or severe according to the results of the function tests, and pancreatic calcifications were assessed semi-quantitatively (grades 1-3) by an independent examiner. The results showed that severe exocrine pancreatic insufficiency did occur even in the absence of calcifications. Calcifications were more frequently detected with increasing severity of exocrine pancreatic insufficiency. The qualitative demonstration of pancreatic calcification was, however, not an indicator of severe, decompensated exocrine pancreatic insufficiency (50% false-positive results). It is concluded that pancreatic calcification is not necessarily an indicator of severe exocrine pancreatic insufficiency, and vice versa. Comparison between the results of tests for endocrine pancreatic function and plain abdominal x-ray showed such similarity that it can also be concluded that pancreatic calcifications are no indication of abnormal endocrine function, and vice versa.
胰腺钙化被认为仅发生在外分泌性胰腺功能不全的晚期。通过将79例慢性胰腺炎患者的促胰液素 - 胰酶泌素试验结果、粪便脂肪分析以及腹部平片上胰腺钙化的情况进行关联，这一观点得到了重新评估。根据功能测试结果，外分泌性胰腺功能不全被分为轻度、中度或重度，并且由一名独立检查者对胰腺钙化进行半定量评估（1 - 3级）。结果显示，即使没有钙化，严重的外分泌性胰腺功能不全也确实会发生。随着外分泌性胰腺功能不全严重程度的增加，钙化的检出频率更高。然而，胰腺钙化的定性显示并非严重失代偿性外分泌性胰腺功能不全的指标（假阳性结果为50%）。结论是，胰腺钙化不一定是严重外分泌性胰腺功能不全的指标，反之亦然。内分泌胰腺功能测试结果与腹部平片结果之间的比较显示出如此相似性，以至于也可以得出结论，胰腺钙化并非内分泌功能异常的指标，反之亦然。
