Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Yonsei Med J. 2024 Nov;65(11):636-644. doi: 10.3349/ymj.2023.0503.
Interest in the quality of life (QoL) of patients with inflammatory bowel disease (IBD) has recently increased. Although measurement tools have been devised for IBD in general, there is no specific tool for measuring the QoL of patients with ulcerative colitis (UC). Therefore, we developed a QoL questionnaire specifically for patients with UC.
The Korean Ulcerative Colitis-Specific Questionnaire (K-UCSQ) was developed through item generation, raw-scale construction, focus group meetings, and multi-center field tests. Two hundred patients with UC were recruited for a field test of the K-UCSQ, and subsequent responses to the Inflammatory Bowel Disease Questionnaire (IBDQ) were also obtained. After performing factor analyses to ensure construct validity, the K-UCSQ was finalized as a four-domain, 28-item questionnaire. Subsequent analyses evaluated the reliability of the K-UCSQ in terms of Cronbach's alpha, concurrent validity in comparison with the pre-established IBDQ, and predictive validity of the area under the ROC curve (AUC) for clinically relevant QoL outcomes.
A Cronbach's alpha of 0.94 showed excellent reliability. Furthermore, correlation analyses demonstrated the concurrent validity of the K-UCSQ in comparison with the IBDQ. The K-UCSQ also showed high validity in predicting the perceived overall health (AUC of 0.812 vs. 0.797 using the IBDQ) and past 2-week QoL (AUC of 0.864 vs. 0.859 using the IBDQ).
The newly developed K-UCSQ is concise, bathroom problem-emphasizing, and UC-specific, suggesting that it could be a valid and reliable UC-specific instrument for QoL measurement.
近来，人们对炎症性肠病（IBD）患者生活质量（QoL）的兴趣有所增加。尽管已经为 IBD 制定了衡量工具，但尚无专门用于衡量溃疡性结肠炎（UC）患者 QoL 的工具。因此，我们专门为 UC 患者开发了一种 QoL 问卷。
通过项目生成、原始量表构建、焦点小组会议和多中心现场测试，开发了韩国溃疡性结肠炎特异性问卷（K-UCSQ）。对 200 名 UC 患者进行了 K-UCSQ 的现场测试，随后还获得了对炎症性肠病问卷（IBDQ）的应答。在进行因子分析以确保结构效度后，K-UCSQ 最终确定为一个包含四个领域、28 个项目的问卷。随后的分析评估了 K-UCSQ 的可靠性，包括 Cronbach 的 alpha、与既定的 IBDQ 的同时效度，以及 ROC 曲线下面积（AUC）对临床相关 QoL 结果的预测效度。
Cronbach 的 alpha 值为 0.94，显示出极好的可靠性。此外，相关分析表明 K-UCSQ 与 IBDQ 具有同时效度。K-UCSQ 还在预测整体感知健康（使用 IBDQ 的 AUC 为 0.812，而使用 K-UCSQ 的 AUC 为 0.864）和过去 2 周 QoL（使用 IBDQ 的 AUC 为 0.859，而使用 K-UCSQ 的 AUC 为 0.864）方面表现出很高的有效性。
新开发的 K-UCSQ 简洁、强调肠道问题且具有 UC 特异性，表明它可能是一种有效的、可靠的 UC 特异性 QoL 衡量工具。
