Mai Qiongdan, Lai Weiming, Deng Wenyu, Guo Junfei, Luo Yasha, Bai Ru, Gu Chunming, Luo Guanbin, Mai Rongjia, Luo Mingyong
Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, People's Republic of China.
Infect Drug Resist. 2024 Oct 18;17:4511-4520. doi: 10.2147/IDR.S486907. eCollection 2024.
Acute gastroenteritis caused by spp. among children post a great threat for global public health. The increasing rate of drug-resistant spp. has also become a challenging problem worldwide. In this study, the prevalence, serotypes, and antimicrobial characteristics of isolated from children in Guangzhou, China, were investigated to provide supporting information for clinical treatment and prevention.
Clinical data of children featured with gastroenteritis symptoms from 2018 to 2023 in Guangdong Women and Children Hospital were collected. The difference and fluctuation of antimicrobial resistance between serotypes and years were retrospectively analyzed.
A total of 1304 isolates were cultural-confirmed. The overall positive rate of isolated from stool samples was 22.0% (1304/5924). infections occur mainly from June to September and the majority of infected children aged under 4 years. Serogroup B was the most common serogroup among isolates (74.6%, 973/1304). The predominant serotypes of isolates were Typhimurium (63.1%, 823/1304). Higher drug resistance rate of spp. to ceftriaxone was observed in 2023. The drug resistance rates of isolates to sulfamethoxazole/trimethoprim and ampicillin are at high level during the past 6 years. Notably, higher multi-drug resistance (MDR) rate was demonstrated in Typhimurium compared with other serotypes.
Typhimurium was the most common serotype isolated from children in Guangzhou, China, and it may mainly account for the high drug resistance rate in spp. to most of the antimicrobial profiles. For controlling the high drug resistance rate of spp. continuous surveillance of drug resistance and appropriate use of antibiotics based on clinical and laboratory results are of great significance.
由[具体菌名]引起的儿童急性肠胃炎对全球公共卫生构成重大威胁。[具体菌名]耐药率的上升也已成为全球范围内一个具有挑战性的问题。本研究调查了从中国广州儿童中分离出的[具体菌名]的流行情况、血清型及抗菌特性，为临床治疗和预防提供支持信息。
收集了2018年至2023年在广东省妇幼保健院出现肠胃炎症状儿童的临床资料。回顾性分析血清型和年份之间抗菌耐药性的差异和波动情况。
共1304株[具体菌名]分离株经培养确认。从粪便样本中分离出的[具体菌名]总体阳性率为22.0%（1304/5924）。[具体菌名]感染主要发生在6月至9月，大多数感染儿童年龄在4岁以下。B血清群是[具体菌名]分离株中最常见的血清群（74.6%，973/1304）。[具体菌名]分离株的主要血清型为鼠伤寒血清型（63.1%，823/1304）。2023年观察到[具体菌名]对头孢曲松的耐药率较高。在过去6年中，[具体菌名]分离株对磺胺甲恶唑/甲氧苄啶和氨苄西林的耐药率处于较高水平。值得注意的是，与其他血清型相比，鼠伤寒血清型的[具体菌名]表现出更高的多重耐药（MDR）率。
鼠伤寒血清型是从中国广州儿童中分离出的最常见血清型，它可能是[具体菌名]对大多数抗菌谱耐药率高的主要原因。为控制[具体菌名]的高耐药率，持续进行耐药性监测并根据临床和实验室结果合理使用抗生素具有重要意义。
