Chen Huiyu, Qiu Huahong, Zhong Hui, Cheng Feng, Wu Zhihui, Shi Tengfei
Department of Clinical Laboratory, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China.
Department of Laboratory Medicine, Fujian Children's Hospital, Fujian Provincial Maternity and Children's Hospital, Fuzhou, Fujian, People's Republic of China.
Infect Drug Resist. 2023 May 6;16:2737-2749. doi: 10.2147/IDR.S408152. eCollection 2023.
Non-typhoidal (NTS) infection is a leading cause of acute gastroenteritis in children. Recently, NTS infections have increased, especially those associated with Typhimurium, which has become a global problem because of its high level of drug resistance. Diseases caused by NTS serotypes vary considerably. We summarised NTS infections among children in Fuzhou, Fujian, China, from 2012 to 2021, and synthesised studies indicating the clinical symptoms, laboratory test results, and drug resistance associated with . Typhimurium and non-. Typhimurium to enhance the knowledge of these infections and improve their diagnoses and treatment.
Between January 2012 and December 2021, 691 children with NTS infections confirmed by positive culture test results were recruited from Fujian Children's Hospital and Fujian Maternity and Child Health Hospital. Clinical demographic data of each case were collected from the electronic medical records and analysed.
A total of 691 isolates were identified. The number of NTS infections increased significantly in 2017 and increased sharply during 2020 and 2021, especially . Typhimurium greatly increased and was the dominant serotype (58.3%). . Typhimurium infection was commonly occurred in children younger than 3 years and most of them were gastrointestinal infection, while non-. Typhimurium more often observed in older children and associated with extra-intestinal infection. The rate of multidrug-resistant . Typhimurium was significantly higher than that of non-. Typhimurium, especially during the last 2 years of this study (2020 and 2021).
. Typhimurium was the dominant serotype and greatly increased among children in Fuzhou city. There are significant differences in clinical symptoms, laboratory test results, and drug resistance between . Typhimurium and non-. Typhimurium. More attention should be paid on . Typhimurium. Long-term high-quality surveillance and control measures should be conducted to prevent salmonella infections and drug resistance.
非伤寒沙门氏菌（NTS）感染是儿童急性胃肠炎的主要病因。近年来，NTS感染有所增加，尤其是与鼠伤寒沙门氏菌相关的感染，由于其高度耐药性，已成为一个全球性问题。NTS血清型引起的疾病差异很大。我们总结了2012年至2021年中国福建福州儿童的NTS感染情况，并综合了表明与鼠伤寒沙门氏菌和非鼠伤寒沙门氏菌相关的临床症状、实验室检查结果及耐药性的研究，以增进对这些感染的了解并改善其诊断和治疗。
2012年1月至2021年12月期间，从福建儿童医院和福建省妇幼保健院招募了691例培养检测结果呈阳性而确诊为NTS感染的儿童。从电子病历中收集每个病例的临床人口统计学数据并进行分析。
共鉴定出691株菌株。2017年NTS感染数量显著增加，在2020年和2021年急剧上升，尤其是鼠伤寒沙门氏菌大幅增加且为优势血清型（58.3%）。鼠伤寒沙门氏菌感染常见于3岁以下儿童，且大多数为胃肠道感染，而非鼠伤寒沙门氏菌在年龄较大儿童中更常见且与肠外感染有关。多重耐药鼠伤寒沙门氏菌的比例显著高于非鼠伤寒沙门氏菌，尤其是在本研究的最后两年（2020年和2021年）。
鼠伤寒沙门氏菌是福州市儿童中的优势血清型且大幅增加。鼠伤寒沙门氏菌和非鼠伤寒沙门氏菌在临床症状、实验室检查结果及耐药性方面存在显著差异。应更加关注鼠伤寒沙门氏菌。应采取长期高质量的监测和控制措施以预防沙门氏菌感染及耐药性。
