Li Yuanyuan, Yi Shanting, Jiang Wencai, Gong Meihui
Cardiovascular Center of the Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, 519000, People's Republic of China.
Department of Cardiology, Suining Central Hospital, Suining, 629000, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Oct 18;17:3817-3832. doi: 10.2147/DMSO.S491255. eCollection 2024.
Previous studies have established a strong association between obesity, high metabolism, and the development of hyperuricemia. However, the relationship between obesity metabolism indices and hyperuricemia in high-risk patients with hypertension and coronary heart disease (CHD) remains unclear. The purpose of this study was to investigate this relationship in patients with both hypertension and CHD, and to identify the obesity metabolism index with the best diagnostic value.
A two-center study encompassed 6344 participants with hypertension and CHD. Multiple logistic regression was utilized to examine the correlation between six obesity metabolism indices and hyperuricemia, with restricted cubic spline (RCS) analysis to identify non-linear relationships. Diagnostic value was assessed via receiver operating characteristic (ROC) curves and decision curve analysis (DCA).
Multivariable logistic regression revealed a significant correlation between increased obesity metabolism indices and hyperuricemia. Furthermore, RCS analysis revealed a nonlinear dose-response relationship (P for nonlinear < 0.001). Moreover, ROC and DCA results showed that METS-VF index, which combined visceral obesity and metabolic parameters, became the most reliable diagnostic tool.
The study underscores a strong association between elevated obesity metabolism indices and hyperuricemia in patients with hypertension and CHD. The METS-VF index, amalgamating visceral obesity and metabolic parameters, emerged as the most reliable diagnostic tool.
先前的研究已证实肥胖、高代谢与高尿酸血症的发生之间存在密切关联。然而，高血压和冠心病（CHD）高危患者的肥胖代谢指标与高尿酸血症之间的关系仍不明确。本研究的目的是调查高血压和冠心病患者中的这种关系，并确定具有最佳诊断价值的肥胖代谢指标。
一项双中心研究纳入了6344名高血压和冠心病患者。采用多因素logistic回归分析六个肥胖代谢指标与高尿酸血症之间的相关性，并通过限制性立方样条（RCS）分析确定非线性关系。通过受试者工作特征（ROC）曲线和决策曲线分析（DCA）评估诊断价值。
多变量logistic回归显示肥胖代谢指标升高与高尿酸血症之间存在显著相关性。此外，RCS分析显示存在非线性剂量反应关系（非线性P<0.001）。此外，ROC和DCA结果表明，结合内脏肥胖和代谢参数的METS-VF指数成为最可靠的诊断工具。
该研究强调了高血压和冠心病患者中肥胖代谢指标升高与高尿酸血症之间的密切关联。结合内脏肥胖和代谢参数的METS-VF指数成为最可靠的诊断工具。
