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一种以ADSS作为核心基因的乳腺癌新临床预后模型。

A new clinical prognosis model for breast cancer with ADSS as the hub gene.

作者信息

Zhang Zhi, Xu Fei, Zeng Suna, Li Xiaoying, Cai Yuzhe, Li Jinghua, Peng Zha, Chen Yixuan, Huang Chengyu, Li Ting, Mo Steven, Zhao Tongling, Huang Hai

机构信息

Department of Hepatobiliary Surgery, Guangxi Medical University Affliated Wuming Hospital, Nanning 530199, China.

Experimental Center of BIOQGene, YuanDong International Academy of Life Sciences, Hong Kong 999077, China.

出版信息

J Cancer. 2024 Sep 16;15(18):5910-5926. doi: 10.7150/jca.95589. eCollection 2024.

DOI:10.7150/jca.95589
PMID:39440049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11492999/
Abstract

Breast cancer (BRCA) is the most common malignant tumor and the leading cause of cancer death worldwide. Adenylosuccinate synthetase (ADSS) is highly expressed in BRCA and its subtypes malignant tumors and is associated with poor prognosis. By applying ROC curve, survival analysis, WGCNA, enrichment analysis, Cox regression model and other methods, this study explores the role of ADSS in BRCA and constructs a scoring model. In this study, the ADSS demonstrated good diagnostic efficacy and high expression in breast cancer tissues. Further exploration of the role of ADSS in BRCA revealed that its significantly related coexpressed genes are clearly involved in biological functions and signaling pathways associated with cell proliferation and differentiation. Additionally, the ADSS-related scoring model showed a significant prognostic impact on clinical characteristics, such as metastasis to lymph nodes, and it was discovered that the ADSS score and related scoring genes may affect the immune microenvironment of BRCA patients, potentially participating in the occurrence of this disease. In summary, our gene expression analysis of ADSS in BRCA generated a clinical scoring model based on the ADSS that may be used to assess prognostic risk and provide potential clinical applications and rational therapeutic targets.

摘要

乳腺癌（BRCA）是全球最常见的恶性肿瘤，也是癌症死亡的主要原因。腺苷酸琥珀酸合成酶（ADSS）在BRCA及其亚型恶性肿瘤中高表达，且与预后不良相关。本研究通过应用ROC曲线、生存分析、加权基因共表达网络分析（WGCNA）、富集分析、Cox回归模型等方法，探讨ADSS在BRCA中的作用并构建评分模型。在本研究中，ADSS在乳腺癌组织中显示出良好的诊断效能和高表达。对ADSS在BRCA中的作用进一步探索发现，其显著相关的共表达基因明显参与了与细胞增殖和分化相关的生物学功能和信号通路。此外，ADSS相关评分模型对临床特征（如淋巴结转移）有显著的预后影响，并且发现ADSS评分和相关评分基因可能影响BRCA患者的免疫微环境，可能参与该疾病的发生。总之，我们对BRCA中ADSS的基因表达分析基于ADSS生成了一个临床评分模型，该模型可用于评估预后风险，并提供潜在的临床应用和合理的治疗靶点。

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