基于 Ru(II) 配合物的 COX-2 靶向型 I 型光引发剂诱导铁死亡和细胞凋亡。
A Ru(II) complex-based COX-2 targeting type I photosensitizer evokes ferroptosis and apoptosis.
机构信息
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center, Nanjing University, Nanjing 210023, Jiangsu, P. R. China.
Kai Yuan School of Innovation and Entrepreneurship, Wuxi Institute of Technology, Wuxi 214121, China.
出版信息
Chem Commun (Camb). 2024 Nov 5;60(89):13091-13094. doi: 10.1039/d4cc04217d.
Photodynamic therapy (PDT) often faces challenges such as oxygen dependence and limited tumour specificity. We report a tumour-targeting photosensitizer (PS), RuCXB, which enhances uptake by cancer cells by targeting overexpressed cyclooxygenase-2 enzyme in tumours. RuCXB also reduces oxygen dependence a type I PDT mechanism and achieves a strong therapeutic effect through the synergistic induction of ferroptosis and apoptosis. This work presents a reliable strategy for developing potent PSs with enhanced PDT efficacy, tumour selectivity, and diminished oxygen dependence.
光动力疗法（PDT）常面临氧气依赖性和肿瘤特异性有限等挑战。我们报告了一种肿瘤靶向光敏剂（PS）RuCXB，它通过靶向肿瘤中过表达的环氧化酶-2 酶来增强癌细胞的摄取。RuCXB 还降低了氧气依赖性——一种 I 型 PDT 机制，并通过协同诱导铁死亡和细胞凋亡来实现强大的治疗效果。这项工作为开发具有增强的 PDT 疗效、肿瘤选择性和降低氧气依赖性的强效 PS 提供了一种可靠的策略。
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