First insights into the prevalence, genetic characteristics, and pathogenicity of from generations worldwide.

, a global threat, is one of the major causes of toxin-induced foodborne diseases. However, a comprehensive assessment of the prevalence and characteristics of worldwide is still lacking. Here, we applied whole-genome sequence analysis to 191 collected in Africa, America, Asia, Europe, and Oceania from the 1900s to 2022, finding that CC142 dominated the global clonal complex. The results provided direct evidence that could spread through the food chain and intercontinentally. from different generations worldwide showed coherence in the antibiotic-resistant gene and virulence and biofilm gene profiles, although with high genomic heterogeneity. The profiles and virulence and biofilm genes were detected at high rates, and we emphasized that would pose a serious challenge to global public health and clinical treatment.IMPORTANCEThis study first emphasized the prevalence, genetic characteristics, and pathogenicity of worldwide from the 1900s to 2022 using whole-genome sequence analysis. The CC142 dominated the global clonal complex. Moreover, we revealed a close evolutionary relationship between the isolates from different sources. isolates from different generations worldwide showed coherence in potential pathogenicity, although with high genomic heterogeneity. The profiles and virulence and biofilm genes were detected at high rates, and we emphasized that would pose a serious challenge to global public health and clinical treatment.