Wang Zhiming, Liu Chang, Wu Yuanyuan, Yao Huirong, He Song, Zhao Liancheng, Zeng Xianshun
Tianjin Key Laboratory for Photoelectric Materials and Devices, and Key Laboratory of Display Materials & Photoelectric Devices, Ministry of Education, School of Materials Science & Engineering, Tianjin University of Technology, Tianjin, 300384, China.
School of Materials Science & Engineering, Institute of Information Functional Materials & Devices, Harbin Institute of Technology, Harbin, 150001, China.
J Fluoresc. 2024 Oct 23. doi: 10.1007/s10895-024-03994-1.
Glyoxal (GL) is a physiological reactive α-oxoaldehyde metabolite, produced by lipid peroxidation and autoxidation of glucose. In this work, a specific mitochondria-targeting fluorescent probe Z-GL for glyoxal has been developed by an introducing isopropyl group on the recognition site to tune the selectivity toward glyoxal. The probe showed high selectivity and sensitivity for glyoxal in an aqueous system. Importantly, the probe was able to visualize exogenous and endogenous glyoxal in living cells. Furthermore, the probe was mitochondria-targetable, and could be used for monitoring the level of intracellular glyoxal.
乙二醛（GL）是一种生理性反应性α-氧代醛代谢产物，由脂质过氧化和葡萄糖的自氧化产生。在这项工作中，通过在识别位点引入异丙基来调节对乙二醛的选择性，开发了一种用于乙二醛的特异性线粒体靶向荧光探针Z-GL。该探针在水体系中对乙二醛表现出高选择性和高灵敏度。重要的是，该探针能够可视化活细胞中外源性和内源性乙二醛。此外，该探针可靶向线粒体，可用于监测细胞内乙二醛水平。
