Azad University, Science and Research Unit, Tehran, Iran.
Functional Fibrous Structures & Environmental Enhancement (FFSEE), Department of Textile Engineering, Amirkabir University of Technology, Tehran, Iran.
World J Microbiol Biotechnol. 2024 Oct 23;40(11):361. doi: 10.1007/s11274-024-04170-0.
Concentration control of some drug are used commonly however their uncontrolled concentration renders severe side effects. Therefore, it is substantial to come up with innovation release control methods. There is a strong affinity between the phospholipid of nanoliposomes and wool cells which facilitate the diffusion of liposomes into the wool structure. On the other hand, polyhexamethylene biguanide (PHMB) has gained popularity as an antibacterial agent; however, the compound's cytotoxicity has limited its usefulness. By compounding these facts, this work introduces a novel method for sustained drug release via internalization. In this method, PHMB was detained into nanoliposomes infiltrated the wool to generate an extremely regulated release, which was established using various techniques. SEM pictures demonstrated effective absorption of nanoliposome-encapsulated PHMB within the wool fabric. The developed wound dressing showed a sustained drug release, and consequently, perfect biocompatibility and enduring antibacterial activity.
一些药物的浓度控制通常被使用，然而它们不受控制的浓度会导致严重的副作用。因此，提出创新的释放控制方法是非常重要的。纳米脂质体的磷脂与羊毛细胞之间具有很强的亲和力，这有助于脂质体扩散到羊毛结构中。另一方面，聚六亚甲基双胍（PHMB）作为一种抗菌剂已经广受欢迎；然而，该化合物的细胞毒性限制了其用途。基于这些事实，本工作提出了一种通过内化实现药物持续释放的新方法。在这种方法中，PHMB 被扣留到纳米脂质体中，然后渗透到羊毛中，以产生非常规律的释放，这是通过各种技术建立的。SEM 图片表明，纳米脂质体包封的 PHMB 有效地被吸收到羊毛织物中。所开发的伤口敷料显示出持续的药物释放，因此具有良好的生物相容性和持久的抗菌活性。
