School of Material Science & Engineering, University of Science and Technology Beijing, Beijing 10083, PR China.
School of Material Science & Engineering, University of Science and Technology Beijing, Beijing 10083, PR China.
Carbohydr Polym. 2019 Oct 15;222:114985. doi: 10.1016/j.carbpol.2019.114985. Epub 2019 Jun 10.
In recent years, bacterial cellulose (BC)-based dressings or patches for skin or soft tissue repair have become investigative emphasis. However, most of the BC-based products used for biomedical applications present limitations due to their low flexibility, poor gas permeability and no inherent antibacterial activity. Herein, we proposed and designed a novel composite composed of natural bacterial cellulose (BC), polyethylene glycol (PEG) and polyhexamethylene biguanidine (PHMB) through new synthetic approaches. The composite membrane exhibited favorable physicochemical performance, especially transparency, water retention ability, flexibility as well as the characteristic of anti-adhesion. In vitro biochemical experiment results indicated that the composite had excellent biocompatibility and exhibited strong and sustained antibacterial effect. In vivo test further demonstrated that the composite could efficiently promote skin wound healing and regeneration in a rat model. This composite membrane possesses multiple mechanisms of promoting cutaneous wound healing and will provide new ideas for future development of wound dressings.
近年来，基于细菌纤维素（BC）的敷料或贴片在皮肤或软组织修复方面的研究受到了关注。然而，大多数用于生物医学应用的 BC 基产品由于其低弹性、差的透气性和没有内在的抗菌活性而存在局限性。在此，我们通过新的合成方法提出并设计了一种由天然细菌纤维素（BC）、聚乙二醇（PEG）和聚六亚甲基双胍（PHMB）组成的新型复合材料。该复合膜具有良好的物理化学性能，特别是透明度、保水能力、柔韧性以及抗粘连特性。体外生化实验结果表明，该复合材料具有良好的生物相容性，并表现出强大且持续的抗菌作用。体内试验进一步证明，该复合材料能够有效地促进大鼠模型皮肤伤口的愈合和再生。这种复合膜具有多种促进皮肤伤口愈合的机制，为未来伤口敷料的发展提供了新的思路。
