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老年人血脂异常的患病率及相关因素:伊朗 Ardakan 老龄化队列研究的结果。

Prevalence and associated factors of dyslipidemia in elderly people: Results from the Ardakan Cohort Study on Ageing, Iran.

机构信息

Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran/Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

出版信息

PLoS One. 2024 Oct 23;19(10):e0306388. doi: 10.1371/journal.pone.0306388. eCollection 2024.

Abstract

BACKGROUND AND OBJECTIVE

Dyslipidemia is a major modifiable factor in elderly people. The study objective was to assess the prevalence and associated risk factors of dyslipidemia among the Iranian population aged over 50.

METHODS

This population-based cross-sectional study is part of the Iranian Longitudinal Study on Ageing conducted in Ardakan, Iran. In total, 5,197 participants aged over 50 years old were included through a stratified random sampling method. Dyslipidemia was defined in compliance with the Adult Treatment Panel III criteria. The Chi-square and independent sample t-test were used to compare categorical and quantitative variables, respectively. A logistic regression analysis was applied to determine associated factors of dyslipidemia.

RESULTS

The mean age of the participants was 62.24±7.52. The prevalence of dyslipidemia was 68.85%. High levels of total cholesterol, triglyceride, low-density lipoprotein, and low level of high-density lipoprotein were seen among 9.74%, 24.66%, 5.54%, 19.20% of the participants, respectively. In addition, 66.05% of the study participants were under the treatment of lipid-lowering medications. Among the possible investigated risk factors of dyslipidemia, male gender (odds ratio (OR) = 0.56, 95% confidence interval (CI): 0.47, 0.68), waist circumference (OR = 1.03, 95%CI: 1.02, 1.04), diabetes mellitus (OR = 2.28, 95%CI: 1.96, 2.66), and hypertension (OR = 1.59, 95%CI: 1.38, 1.83) showed a statistically significant association (p<0.05).

CONCLUSION

Dyslipidemia is highly prevalent in Ardakan's older population. So, lipid management interventions are necessary for this population.

摘要

背景与目的

血脂异常是老年人的一个主要可调节因素。本研究旨在评估伊朗 50 岁以上人群血脂异常的患病率及其相关危险因素。

方法

这是一项基于人群的横断面研究,是伊朗老年纵向研究的一部分,在伊朗阿尔达坎进行。共纳入了 5197 名年龄在 50 岁以上的通过分层随机抽样方法的参与者。血脂异常的定义符合成人治疗小组 III 标准。使用卡方检验和独立样本 t 检验分别比较分类变量和定量变量。应用逻辑回归分析确定血脂异常的相关因素。

结果

参与者的平均年龄为 62.24±7.52 岁。血脂异常的患病率为 68.85%。总胆固醇、甘油三酯、低密度脂蛋白和高密度脂蛋白水平升高的患者比例分别为 9.74%、24.66%、5.54%和 19.20%。此外,66.05%的研究参与者正在服用降脂药物。在血脂异常的可能危险因素中,男性(比值比(OR)=0.56,95%置信区间(CI):0.47,0.68)、腰围(OR=1.03,95%CI:1.02,1.04)、糖尿病(OR=2.28,95%CI:1.96,2.66)和高血压(OR=1.59,95%CI:1.38,1.83)与血脂异常有统计学显著关联(p<0.05)。

结论

阿尔达坎的老年人群中血脂异常的患病率很高。因此,需要对该人群进行血脂管理干预。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/915a/11498658/c50807bccedd/pone.0306388.g001.jpg

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