Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Sci Rep. 2022 Jul 7;12(1):11504. doi: 10.1038/s41598-022-13926-3.
The potential effects of opium consumption on lipid profile remain unquantified. We considered the association between opium use and dyslipidemia. In this cross-sectional study, we used data obtained from the Rafsanjan cohort study, as a part of the prospective epidemiological research studies in IrAN (PERSIAN) with detailed and validated data on opium consumption and selected other exposures. A total of 9932 adults were included in the study. Logistic regression models were used to assess the relationships of opium consumption with the prevalence of dyslipidemia and lipid disorders. In this population, 73.33% had dyslipidemia and the prevalence rates of high TC, high TG, high LDL and low HDL were 54.24%, 47.45%, 34.43% and 11.91% respectively. After adjustment for all confounders, opium users compared with non-users had lower odds ratios (OR) of high TC and high LDL [0.81 (95% confidence interval, CI 0.71-0.92) and 0.80 (95% CI 0.69-0.93) respectively] and greater OR of low HDL [1.30 (95% CI 1.04-1.62)]. Longer duration of opium consumption resulted in lower ORs of high TC, 0.68 (95% CI 0.55-0.84) and high LDL, 0.82 (95% CI 0.67-0.99), and shorter duration of opium consumption resulted in increased odds of low HDL, 1.30 (95% CI 1.02-1.66). High dose of opium consumption was associated with an OR of dyslipidemia of 0.80 (95% CI 0.65-0.97), high TC of 0.80 (95% CI 0.67-0.95), and high LDL of 0.78 (95% CI 0.64-0.96) and low dose of opium consumption, with an OR of low HDL of 1.30 (95% CI 1.02-1.65). In relation to route of consumption, opium smoking was a risk factor for low HDL with an adjusted odds ratio of 1.31 (1.04-1.63). Opium use was associated with selected changes on serum lipid levels, but opium users had higher frequency of cardiovascular disease history.
鸦片消费对血脂谱的潜在影响尚未量化。我们考虑了鸦片使用与血脂异常之间的关联。在这项横断面研究中，我们使用了来自拉夫桑詹队列研究的数据，该研究是伊朗前瞻性流行病学研究（PERSIAN）的一部分，该研究详细且验证了关于鸦片消费和其他选定暴露因素的数据。共有 9932 名成年人纳入了研究。我们使用逻辑回归模型评估了鸦片消费与血脂异常和血脂紊乱患病率之间的关系。在该人群中，73.33%的人血脂异常，高 TC、高 TG、高 LDL 和低 HDL 的患病率分别为 54.24%、47.45%、34.43%和 11.91%。在调整所有混杂因素后，与非使用者相比，鸦片使用者发生高 TC 和高 LDL 的比值比（OR）较低[0.81（95%置信区间，CI 0.71-0.92）和 0.80（95%CI 0.69-0.93）]，低 HDL 的比值比（OR）较高[1.30（95%CI 1.04-1.62）]。鸦片消费持续时间较长与高 TC、0.68（95%CI 0.55-0.84）和高 LDL、0.82（95%CI 0.67-0.99）的比值比降低有关，而鸦片消费持续时间较短与低 HDL 的比值比升高有关，1.30（95%CI 1.02-1.66）。高剂量鸦片消费与血脂异常的 OR 为 0.80（95%CI 0.65-0.97），高 TC 的 OR 为 0.80（95%CI 0.67-0.95），高 LDL 的 OR 为 0.78（95%CI 0.64-0.96），低剂量鸦片消费与低 HDL 的 OR 为 1.30（95%CI 1.02-1.65）。就消费途径而言，鸦片吸烟是低 HDL 的危险因素，调整后的比值比为 1.31（1.04-1.63）。鸦片使用与血清脂质水平的某些变化有关，但鸦片使用者患心血管疾病的频率更高。
