Polydopamine (PDA)-based materials inspired by the adhesive proteins of mussels have attracted increasing attention owing to the universal adhesiveness, antioxidant activity, fluorescence quenching ability, excellent biocompatibility, and especially photothermal conversion capability. The high binding ability of PDA to a variety of metal ions offers a paradigm for the exploration of metal-chelated polydopamine nanomaterials with fantastic properties and functions. This review systematically summarizes the latest progress of metal-chelated polydopamine nanomaterials for the applications in biomedicine, catalysis, and energy storage. Different fabrication strategies for metal-chelated polydopamine nanomaterials with various composition, structure, size, and surface chemistry, such as the pre-functionalization method, the one-pot co-assembly method, and the post-modification method, are summarized. Furthermore, emerging applications of metal-chelated polydopamine nanomaterials in the fields ranging from cancer therapy, theranostics, antibacterial, catalysis to energy storage are highlighted. Additionally, the critical remaining challenges and future directions of this area are discussed to promote the further development and practical applications of PDA-based materials.