Physivitrins I-R，来自真菌 Physisporinus vitreus 的具有抗炎活性的羊毛甾烷三萜。
Physivitrins I-R, lanostane triterpenoids with anti-inflammatory activities from the fungus Physisporinus vitreus.
机构信息
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China; International Cooperation Base for Active Substances in Traditional Chinese Medicine in Hubei Province, Wuhan, 430074, China; National Demonstration Center for Experimental Ethnopharmacology Education, South-Central Minzu University, Wuhan, 430074, China.
出版信息
Phytochemistry. 2025 Jan;229:114314. doi: 10.1016/j.phytochem.2024.114314. Epub 2024 Oct 22.
Chemical investigation on the rice fermentation of the fungus Physisporinus vitreus led to the isolation of ten previously undescribed lanostane triterpenoids, physivitrins I-R, and three known analogues. The new structures were elucidated on the basis of extensive spectroscopic methods, including 1D & 2D NMR, HRESIMS, UV and ECD. Physivitrins I and P exhibited significant inhibitory activities against NO production in LPS-activated RAW267.4 macrophages with IC values of 8.2 and 11.5 μM, respectively. The comprehensive data indicated that P. vitreus is rich in lanostane triterpenes and has potential anti-inflammatory application prospects.
真菌 Physisporinus vitreus 的大米发酵产物的化学成分研究导致了十种以前未描述的羊毛甾烷三萜的分离，即 physivitrins I-R 和三种已知类似物。新结构是基于广泛的光谱方法，包括 1D 和 2D NMR、HRESIMS、UV 和 ECD 来阐明的。Physivitrins I 和 P 对 LPS 激活的 RAW267.4 巨噬细胞中的 NO 产生表现出显著的抑制活性，IC 值分别为 8.2 和 11.5 μM。综合数据表明，P. vitreus 富含羊毛甾烷三萜，具有潜在的抗炎应用前景。
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