灵芝子实体中的羊毛甾烷三萜类化合物及其抗炎活性。
Lanostane Triterpenoids from the Fruiting Bodies of and Their Anti-Inflammatory Activities.
机构信息
Department of Food Science and Nutrition, School of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University, Hangzhou 310058, China.
The Key Laboratory of Plant Resources and Chemistry of Arid Zone, and State Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.
出版信息
Molecules. 2020 Oct 19;25(20):4807. doi: 10.3390/molecules25204807.
In the current study, further chemical investigation of the fruiting bodies of led to isolate seven new 24-methyl-lanostane triterpenoids, named officimalonic acids I-O (-). Their structures were elucidated based on the analysis of spectroscopic data (HR-MS, 1D and 2D NMR, UV, IR). Compounds - possessed an unusual C-23 spirostructure moiety, while compounds - had 23,26-lactone unit. Anti-inflammatory assay revealed that compounds and exhibited significant inhibitory activities against NO production in LPS-induced RAW 264.7 cells and cyclooxygenase (COX-2).
在本研究中，对 的子实体进行了进一步的化学研究，分离得到了 7 个新的 24-甲基-羊毛甾烷三萜，命名为 officimalonic 酸 I-O（-）。基于光谱数据分析（高分辨质谱、1D 和 2D NMR、UV、IR）确定了它们的结构。化合物-具有不寻常的 C-23 螺结构部分，而化合物-具有 23,26-内酯单元。抗炎试验表明，化合物 和 对 LPS 诱导的 RAW 264.7 细胞中 NO 产生和环氧化酶（COX-2）具有显著的抑制活性。
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