Tongde Hospital of Zhejiang Province, Hangzhou 310012, China.
The 903rd Hospital of People's Liberation Army, Hangzhou 310013, China.
Exp Gerontol. 2024 Nov;197:112614. doi: 10.1016/j.exger.2024.112614. Epub 2024 Oct 23.
This comprehensive review examines the relationship between osteoarthritis (OA) and osteoporosis (OP), two common disorders in the elderly. OA involves joint cartilage degeneration and pain, while OP leads to fractures due to reduced bone mass. Despite different pathologies, both conditions share risk factors such as age and genetics. Studies reveal mixed results: some show higher bone mineral density (BMD) in OA patients, suggesting an inverse relationship, while others find no significant link. Proposed mechanisms include mechanical loading, bone remodeling, and inflammation. Clinical strategies focus on maintaining bone health in OA and monitoring joint health in OP, with treatments like bisphosphonates and exercise. Understanding these interactions is crucial for developing integrated treatments to improve patient outcomes and quality of life. Further research is needed to clarify these complex mechanisms.
这篇全面综述探讨了骨关节炎（OA）和骨质疏松症（OP）这两种老年人常见疾病之间的关系。OA 涉及关节软骨退化和疼痛，而 OP 则由于骨量减少导致骨折。尽管两种疾病的病理机制不同，但它们具有相同的危险因素，如年龄和遗传因素。研究结果显示出混合结果：一些研究表明 OA 患者的骨矿物质密度（BMD）较高，表明存在相反的关系，而另一些研究则没有发现明显的联系。提出的机制包括机械负荷、骨重塑和炎症。临床策略侧重于维持 OA 患者的骨骼健康和监测 OP 患者的关节健康，治疗方法包括双膦酸盐和运动。了解这些相互作用对于制定综合治疗方案以改善患者的预后和生活质量至关重要。需要进一步研究来阐明这些复杂的机制。
