Shimizu Nozomi, Jinnouchi Hiroshige, Kato Katsuhito, Yamagishi Kazumasa, Kihara Tomomi, Takada Midori, Otsuka Toshiaki, Kawada Tomoyuki, Tamakoshi Akiko, Iso Hiroyasu
Department of Hygiene and Public Health, Nippon Medical School.
Department of Public Health Medicine, Institute of Medicine, and Health Services Research and Development Center, University of Tsukuba.
J Atheroscler Thromb. 2025 Apr 1;32(4):502-512. doi: 10.5551/jat.64938. Epub 2024 Oct 24.
Few studies have investigated the impact of sleep duration at night and daytime napping on mortality from aortic disease. In this study, we examined the associations of sleep duration at night with daytime napping and mortality from aortic disease.
We followed 67,269 participants (26,826 men and 40,443 women, aged 40-79 years) who were not night shift workers and had no history of stroke, heart disease, or cancer. The baseline survey was conducted in 1988-1990, and follow-up continued until the end of 2009. Sleep duration at night was classified into three categories: ≤ 6, 7, and ≥ 8 hours/day. We also asked the presence or absence of daytime napping. Hazard ratios (HRs) for mortality from aortic disease with 95% confidence intervals (CIs) were estimated using the Cox proportional hazards model.
During an average 16.3-year follow-up period, we observed 87 deaths from aortic dissection and 82 from aortic aneurysms. There was no association between sleep duration at night and mortality from aortic disease, but daytime napping was associated with an increased risk of mortality from total aortic disease; the multivariable-adjusted HRs were 1.48 [95% CIs: 1.08-2.02]. Furthermore, the stratified analysis revealed a stronger association with medium sleep duration (7 hours at night) compared to the other shorter and longer sleep duration: the multivariable-adjusted HR for aortic disease, 2.02 [1.16-3.52].
Daytime napping but not sleep duration at night was associated with an increased risk of mortality from aortic disease.
很少有研究调查夜间睡眠时间和白天小睡对主动脉疾病死亡率的影响。在本研究中，我们检验了夜间睡眠时间与白天小睡及主动脉疾病死亡率之间的关联。
我们对67269名参与者（26826名男性和40443名女性，年龄在40 - 79岁之间）进行了随访，这些参与者不是夜班工作者，且无中风、心脏病或癌症病史。基线调查于1988 - 1990年进行，随访持续到2009年底。夜间睡眠时间分为三类：≤6小时/天、7小时/天和≥8小时/天。我们还询问了是否有白天小睡的情况。使用Cox比例风险模型估计主动脉疾病死亡率的风险比（HRs）及其95%置信区间（CIs）。
在平均16.3年的随访期内，我们观察到87例主动脉夹层死亡和82例主动脉瘤死亡。夜间睡眠时间与主动脉疾病死亡率之间无关联，但白天小睡与主动脉疾病总死亡率风险增加有关；多变量调整后的HR为1.48 [95% CIs：1.08 - 2.02]。此外，分层分析显示，与其他较短和较长睡眠时间相比，中等睡眠时间（夜间7小时）的关联更强：主动脉疾病的多变量调整后HR为2.02 [1.16 - 3.52]。
与夜间睡眠时间无关，白天小睡与主动脉疾病死亡率风险增加有关。
