抑制非编码翻译的机制。
Mechanisms suppressing noncoding translation.
作者信息
Kesner Jordan S, Wu Xuebing
机构信息
Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Systems Biology, Columbia University Irving Medical Center, New York, NY 10032, USA.
出版信息
Trends Cell Biol. 2024 Oct 22. doi: 10.1016/j.tcb.2024.09.004.
The majority of the DNA sequence in our genome is noncoding and not intended for synthesizing proteins. Nonetheless, genome-wide mapping of ribosome footprints has revealed widespread translation in annotated noncoding sequences, including long noncoding RNAs (lncRNAs), untranslated regions (UTRs), and introns of mRNAs. How cells suppress the translation of potentially toxic proteins from various noncoding sequences remains poorly understood. This review summarizes mechanisms for the mitigation of noncoding translation, including the BCL2-associated athanogene 6 (BAG6)-mediated proteasomal degradation pathway, which has emerged as a unifying mechanism to suppress the translation of diverse noncoding sequences in metazoan cells.
我们基因组中的大部分DNA序列是非编码的，并非用于合成蛋白质。尽管如此，核糖体足迹的全基因组图谱显示，在注释的非编码序列中存在广泛的翻译现象，包括长链非编码RNA（lncRNA）、非翻译区（UTR）和mRNA的内含子。细胞如何抑制来自各种非编码序列的潜在毒性蛋白质的翻译仍知之甚少。本综述总结了减轻非编码翻译的机制，包括BCL2相关抗凋亡基因6（BAG6）介导的蛋白酶体降解途径，该途径已成为抑制后生动物细胞中各种非编码序列翻译的统一机制。
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