Xiao Yinan, Ren Yaru, Hu Wenteng, Paliouras Athanasios R, Zhang Wenyang, Zhong Linghui, Yang Kaixin, Su Li, Wang Peng, Li Yonghong, Ma Minjie, Shi Lei
RNA Oncology Group, School of Public Health, Lanzhou University, Lanzhou, 730000, PR China.
Thoracic surgery department, The First Hospital, Lanzhou University, Lanzhou, 730000, PR China.
Cell Death Discov. 2024 Oct 23;10(1):450. doi: 10.1038/s41420-024-02175-0.
Long non-coding RNAs (lncRNAs) are typically described as RNA transcripts exceeding 200 nucleotides in length, which do not code for proteins. Recent advancements in technology, including ribosome RNA sequencing and ribosome nascent-chain complex sequencing, have demonstrated that many lncRNAs retain small open reading frames and can potentially encode micropeptides. Emerging studies have revealed that these micropeptides, rather than lncRNAs themselves, are responsible for vital functions, including but not limited to regulating homeostasis, managing inflammation and the immune system, moderating metabolism, and influencing tumor progression. In this review, we initially outline the rapidly advancing computational analytical methods and public tools to predict and validate the potential encoding of lncRNAs. We then focus on the diverse functions of micropeptides and their underlying mechanisms in the pathogenesis of disease. This review aims to elucidate the functions of lncRNA-encoded micropeptides and explore their potential applications as therapeutic targets in cancer.
长链非编码RNA（lncRNAs）通常被描述为长度超过200个核苷酸的RNA转录本，它们不编码蛋白质。包括核糖体RNA测序和核糖体新生链复合物测序在内的技术的最新进展表明，许多lncRNAs保留了小开放阅读框，并且有可能编码微肽。新兴研究表明，这些微肽而非lncRNAs本身负责重要功能，包括但不限于调节体内平衡、管理炎症和免疫系统、调节新陈代谢以及影响肿瘤进展。在这篇综述中，我们首先概述了用于预测和验证lncRNAs潜在编码的快速发展的计算分析方法和公共工具。然后，我们关注微肽的多种功能及其在疾病发病机制中的潜在机制。这篇综述旨在阐明lncRNA编码的微肽的功能，并探索它们作为癌症治疗靶点的潜在应用。
