Slager C J, Hooghoudt T E, Serruys P W, Schuurbiers J C, Reiber J H, Meester G T, Verdouw P D, Hugenholtz P G
J Am Coll Cardiol. 1986 Feb;7(2):317-26. doi: 10.1016/s0735-1097(86)80498-3.
In this study the hypothesis is tested that the motion pattern of small anatomic landmarks, recognizable at the left ventricular endocardial border in the contrast angiocardiogram, reflects the motion of the endocardial wall. To verify this, minute metal markers were inserted in the endocardium of eight pigs with a novel retrograde transvascular approach. Marker motion was subsequently recorded with roentgen cinematography and compared with the motion of the landmarks on the endocardial contours detected from the contrast ventriculogram with an automated contour detection system. Linear regression analysis of the directions of the systolic metal marker and endocardial landmark pathways yielded a correlation coefficient of 0.86 and a standard error of the estimate of 10.3 degrees. Landmark pathways were also measured in 23 normal human left ventriculograms. Normal left ventricular endocardial wall motion during systole, as observed in the 30 degrees right anterior oblique view, is characterized by a dominant inward transverse motion of the opposite anterior and inferoposterior walls and a descent of the base toward the apex. The apex itself is almost stationary. On the basis of these observations, a widely applicable model for the assessment of left ventricular wall motion is described in mathematical terms.
在本研究中，对以下假设进行了检验：在心血管造影中可在左心室心内膜边界识别的小解剖标志的运动模式反映了心内膜壁的运动。为了验证这一点，采用一种新型逆行经血管方法将微小金属标记物插入八头猪的心内膜中。随后用X线电影摄影记录标记物的运动，并与使用自动轮廓检测系统从心室造影中检测到的心内膜轮廓上的标志运动进行比较。收缩期金属标记物和心内膜标志路径方向的线性回归分析得出相关系数为0.86，估计标准误差为10.3度。还对23例正常人的左心室造影进行了标志路径测量。在右前斜30度视图中观察到的正常左心室心内膜壁在收缩期的运动特征为相对的前壁和下后壁的主要向内横向运动以及基部向心尖的下降。心尖本身几乎静止。基于这些观察结果，用数学术语描述了一种广泛适用的评估左心室壁运动的模型。
