The Third Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Sci Rep. 2024 Oct 23;14(1):25089. doi: 10.1038/s41598-024-77283-z.
Background Early-life exposure to famine may influence the occurrence of chronic diseases and aging in midlife among those exposed. This study aims to explore the relationship between exposure to the Chinese Great Famine and aging in middle-aged individuals. Methods Participants born in 1963-1965 (unexposed), 1959-1961 (in utero exposure), and 1955-1957 (childhood exposure) from the Kailuan Study were included. Their biological age at 2010, 2014, and 2018 was investigated, and age acceleration (biological age minus actual age) was calculated to assess aging. Logistic regression analysis was employed to describe the relationship between famine exposure and the aging risk. Subgroup and sensitivity analysis were conducted to explore differences and stability in this relationship among different groups. Results A total of 17,543 participants were included in this study. Among them, 12,762 (72.7%) were male, and 4,781 (27.3%) were female, with 2,543 participants experiencing aging events. Compared to unexposed participants, those exposed during childhood and in utero exhibited a 1.69-fold (OR = 1.69, 95%CI: 1.53-1.87) and 1.22-fold (OR = 1.22, 95%CI: 1.08-1.37) increased risk of aging. Subgroup analysis revealed an interaction with income (P for interaction = 0.008), and additional interaction analysis suggested that increasing income could partially mitigate the detrimental effects of early-life famine exposure. Furthermore, experiencing famine in severely affected regions exacerbated the risk of aging (OR = 1.41, 95%CI: 1.21-1.63). Conclusion Exposure to famine in utero or during childhood may elevate the risk of midlife aging among exposed individuals, and these relationships are influenced by the severity of famine exposure. Increasing income may also help mitigate these effects.Trial registration: Kailuan study, ChiCTRTNRC11001489. Registered July 19, 2015 Retrospectively registered, https//www.chictr.org.cn/showprojEN.html?proj=8050&u_atoken=af46a0dee8d73f320bb5459ab7bbcfa9&u_asig=1a0c381017255295896468605e00cf .
早期生活经历饥荒可能会影响暴露人群中年时慢性疾病和衰老的发生。本研究旨在探讨中国大饥荒暴露与中年个体衰老之间的关系。
纳入了来自开滦研究的参与者，他们出生于 1963-1965 年（未暴露组）、1959-1961 年（胎儿期暴露组）和 1955-1957 年（儿童期暴露组）。调查了他们在 2010 年、2014 年和 2018 年的生物学年龄，并计算了年龄加速（生物学年龄减去实际年龄）来评估衰老。采用 logistic 回归分析描述了饥荒暴露与衰老风险之间的关系。进行了亚组和敏感性分析，以探讨不同组间这种关系的差异和稳定性。
本研究共纳入 17543 名参与者。其中，12762 名（72.7%）为男性，4781 名（27.3%）为女性，有 2543 名参与者发生了衰老事件。与未暴露组相比，儿童期和胎儿期暴露组的衰老风险分别增加了 1.69 倍（OR=1.69，95%CI：1.53-1.87）和 1.22 倍（OR=1.22，95%CI：1.08-1.37）。亚组分析显示，这种关系与收入存在交互作用（P 交互=0.008），进一步的交互分析表明，增加收入可以部分减轻早期生活饥荒暴露的不利影响。此外，在受灾严重地区经历饥荒会增加衰老的风险（OR=1.41，95%CI：1.21-1.63）。
胎儿期或儿童期经历饥荒可能会增加暴露人群中年时衰老的风险，而这些关系受到饥荒暴露严重程度的影响。增加收入可能有助于减轻这些影响。
开滦研究，ChiCTR-NRC11001489。于 2015 年 7 月 19 日注册，前瞻性注册，https://www.chictr.org.cn/showprojEN.html?proj=8050&u_atoken=af46a0dee8d73f320bb5459ab7bbcfa9&u_asig=1a0c381017255295896468605e00cf。
