Department of Anesthesiology, Weifang People's Hospital, No. 151 Guangwen Street, Kuiwen District, Weifang, 261041, China.
Shool of Anesthesiology, Shandong Second Medical University, Weifang, 261053, China.
BMC Anesthesiol. 2024 Oct 23;24(1):382. doi: 10.1186/s12871-024-02773-6.
The purpose of this study is to observe whether there is a difference in the anesthetic effect of remimazolam tosilate and remimazolam besylate in daytime hysteroscopic surgery, so as to provide reference for clinical application.
Fifty patients, aged 18-65 years, ASA I-II, scheduled for hysteroscopy under total intravenous anesthesia were selected. The patients were randomly divided into two groups (n = 25): remimazolam tosilate group (group T) and remimazolam besylate group ( group R). The main observation index was the induction dose of remimazolam; secondary observation indicators were sleep time, anesthesia maintenance time, recovery time, induction maintenance dose of alfentanil, maintenance dose of remimazolam, and incidence of adverse events during anesthesia ( hypertension, hypotension, bradycardia, tachycardia).
There was no significant difference in anesthesia induction dose, recovery time, sleep time, anesthesia maintenance time, and incidence of adverse events during anesthesia ( body movement, cough, hypertension, hypotension, bradycardia, tachycardia) between the two groups (P > 0.05).
There was no significant difference in the anesthetic effect of remimazolam tosilate and remimazolam besylate in daytime hysteroscopic surgery.
Chinese Clinical Trial Registry, ChiCTR2400081688.
本研究旨在观察托西酸瑞马唑仑与苯磺酸瑞马唑仑在日间宫腔镜手术中的麻醉效果是否存在差异，为临床应用提供参考。
选择 50 例行全身静脉麻醉下宫腔镜手术的 18-65 岁 ASA I-II 级患者，随机分为两组（n=25）：托西酸瑞马唑仑组（T 组）和苯磺酸瑞马唑仑组（R 组）。主要观察指标为瑞马唑仑诱导剂量；次要观察指标为睡眠时间、麻醉维持时间、苏醒时间、芬太尼诱导维持剂量、瑞马唑仑维持剂量及麻醉期间不良反应（高血压、低血压、心动过缓、心动过速）发生率。
两组患者麻醉诱导剂量、苏醒时间、睡眠时间、麻醉维持时间及麻醉期间不良反应（体动、咳嗽、高血压、低血压、心动过缓、心动过速）发生率差异无统计学意义（P>0.05）。
托西酸瑞马唑仑与苯磺酸瑞马唑仑在日间宫腔镜手术中的麻醉效果无显著差异。
中国临床试验注册中心，ChiCTR2400081688。
