载银介孔硅对玻璃离子水门汀的影响：物理化学、力学和离子释放分析。
The effect of mesoporous silica doped with silver nanoparticles on glass ionomer cements; physiochemical, mechanical and ion release analysis.
机构信息
Department of Bioclinical Sciences, College of Dentistry, Kuwait University, Safat, Kwait City, 13110, Kuwait.
Department of Chemistry, College of Science, Kuwait University, Safat, P.O. Box 5969, 13060, Kwait City, Kuwait.
出版信息
BMC Oral Health. 2024 Oct 23;24(1):1269. doi: 10.1186/s12903-024-05056-1.
BACKGROUND
The purpose of the study was to evaluate the effect of adding mesoporous silica with silver nanoparticles to conventional glass ionomer cements (GIC) on its, physical, chemical, mechanical properties and ion release analysis.
METHODS
Synthesized mesoporous silica with silver nanoparticles were added in 1, 3 and 5% by weight to the liquid component of GIC forming three experimental groups and compared with plain GIC as control group. Physical and chemical characterization were conducted using nano-computerized tomography (NanoCT) and Fourier transform infrared spectroscopy. Surface microhardness, water sorption and solubility were analyzed. Ion release was investigated using Inductive Coupled Plasma-Optical Emission Spectroscopy and High Performance Liquid Chromatography. Statistical analysis between different groups for the set parameters using parametric and non-parametric tests. The results were analysed using one way analysis of variance (p < 0.05).
RESULTS
Synthesized mesoporous silica with silver nanoparticles were of 7.28 ± 5.0 nm in diameter with a spherical morphology. NanoCT revealed less porosities for 3 wt %. Microhardness showed a statistically significant difference for 5 wt% at day 1 and 21 ( p < 0.0001). Water sorption values decreased significantly on day 14 compared to day 7 for control, 1, 3 and 5 wt%. Control specimens showed highest concentration of fluoride release followed by 5, 3 and 1 wt%.
CONCLUSION
Mesoporous silica with silver nanoparticles modified glass ionomer cements showed comparable microhardness to conventional GIC. Ion release was evident from the modified specimens. Silver remained within the GIC for atleast four weeks following incorporation.
背景
本研究旨在评估在传统玻璃离子水门汀（GIC）中添加载银介孔硅纳米粒子对其物理、化学、机械性能和离子释放分析的影响。
方法
合成的载银介孔硅纳米粒子以 1%、3%和 5%（重量比）添加到 GIC 的液体成分中，形成三个实验组，并与普通 GIC 作为对照组进行比较。采用纳米计算机断层扫描（NanoCT）和傅里叶变换红外光谱对物理化学特性进行了表征。分析了表面显微硬度、吸水率和溶解度。采用电感耦合等离子体-光学发射光谱和高效液相色谱法研究了离子释放情况。使用参数和非参数检验对不同组别的设定参数进行了统计分析。结果采用单因素方差分析（p<0.05）进行分析。
结果
合成的载银介孔硅纳米粒子的直径为 7.28±5.0nm，呈球形形态。NanoCT 显示 3wt%的孔隙率较低。第 1 天和第 21 天，5wt%的显微硬度显示出统计学上的显著差异（p<0.0001）。与第 7 天相比，第 14 天对照组、1wt%、3wt%和 5wt%的吸水率显著降低。对照组释放的氟化物浓度最高，其次是 5wt%、3wt%和 1wt%。
结论
载银介孔硅纳米粒子修饰的玻璃离子水门汀的显微硬度与传统 GIC 相当。改性后的试样显示出明显的离子释放。银在掺入后至少在 GIC 中保留了四周。
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