Öztürk Semra Özkan
Department of Internal Medicine, Mersin City Teaching and Research Hospital, Mersin, Türkiye.
Iran J Public Health. 2024 Apr;53(4):888-894. doi: 10.18502/ijph.v53i4.15565.
Triglyceride-glucose index is a product of triglycerides and fasting plasma glucose (FPG) and is a new index of insulin resistance found to correlate with direct measurements. This study aimed to evaluate the relationship between gallstones and triglyceride-glucose index (TGI).
A total of 210 patients were included in this retrospective study. Overall, 105 patients with gallstones were included in the patient group. Patients with diabetes mellitus, chronic diseases, malignant diseases, and patients using cholesterol-lowering drugs were excluded from the study. Healthy individuals (105 cases) were selected for the control group. TGI was calculated separately for each individual using the following formula: (TGI) = ln (fasting TG (mg/dL) × fasting glucose (mg/dL)/2).
Plasma triglyceride levels were significantly higher in patients with gallstones compared to the control group (=0.001). Plasma HDL, LDL, and total cholesterol did not differ between the groups (>0.05). Fasting blood glucose was significantly higher in patients with gallstones compared to the control group (=0.001). The triglyceride glucose index was significantly higher in patients with gallstones compared to the control group (<0.001). When the relationship between body mass index and TGI was analyzed, TGI was lower in patients with normal BMI compared to overweight or obese patients (<0.001).
Increased triglyceride/glucose index in patients with gallstones is an indicator of insulin resistance. It is instrumental in demonstrating the presence of insulin resistance in patients with gallstones and may be a useful guide in earlier detection, prevention, and treatment of insulin resistance.
甘油三酯-葡萄糖指数是甘油三酯与空腹血糖（FPG）的乘积，是一种新发现的与直接测量结果相关的胰岛素抵抗指标。本研究旨在评估胆结石与甘油三酯-葡萄糖指数（TGI）之间的关系。
本回顾性研究共纳入210例患者。总体而言，患者组包括105例胆结石患者。患有糖尿病、慢性病、恶性疾病的患者以及正在使用降胆固醇药物的患者被排除在研究之外。选择健康个体（105例）作为对照组。使用以下公式分别为每个个体计算TGI：（TGI）=ln（空腹甘油三酯（mg/dL）×空腹血糖（mg/dL）/2）。
与对照组相比，胆结石患者的血浆甘油三酯水平显著更高（P=0.001）。两组之间的血浆高密度脂蛋白、低密度脂蛋白和总胆固醇无差异（P>0.05）。与对照组相比，胆结石患者的空腹血糖显著更高（P=0.001）。与对照组相比，胆结石患者的甘油三酯葡萄糖指数显著更高（P<0.001）。当分析体重指数与TGI之间的关系时，体重指数正常的患者的TGI低于超重或肥胖患者（P<0.001）。
胆结石患者甘油三酯/葡萄糖指数升高是胰岛素抵抗的一个指标。它有助于证明胆结石患者存在胰岛素抵抗，并且可能是早期检测、预防和治疗胰岛素抵抗的有用指导。
