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心包中的小细胞外囊泡调节冠状动脉疾病中的巨噬细胞免疫表型。

Small Extracellular Vesicles in the Pericardium Modulate Macrophage Immunophenotype in Coronary Artery Disease.

作者信息

Ben-Aicha Soumaya, Anwar Maryam, Vilahur Gemma, Martino Fabiana, Kyriazis Panagiotis G, de Winter Natasha, Punjabi Prakash P, Angelini Gianni D, Sattler Susanne, Emanueli Costanza

机构信息

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Cardiovascular Program-ICCC, IR-Hospital Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain.

出版信息

JACC Basic Transl Sci. 2024 Jul 3;9(9):1057-1072. doi: 10.1016/j.jacbts.2024.05.003. eCollection 2024 Sep.

Abstract

Coronary artery disease (CAD) is a major health issue. This study focused on pericardial macrophages and small extracellular vesicles (sEVs) in CAD. The macrophages in CAD patients showed reduced expression of protective markers and unchanged levels of proinflammatory receptors. Similar changes were observed in buffy-coat-derived macrophages when stimulated with CAD pericardial fluid-derived sEVs. The sEV contained miRNA-6516-5p, which inhibited CD36 and affected macrophage lipid uptake. These findings indicate that sEV-mediated miRNA actions contribute to the decrease in protective pericardial macrophages in CAD.

摘要

冠状动脉疾病(CAD)是一个主要的健康问题。本研究聚焦于CAD中的心包巨噬细胞和小细胞外囊泡(sEVs)。CAD患者的巨噬细胞显示出保护性标志物表达降低,促炎受体水平未改变。当用CAD心包液来源的sEVs刺激时,在血沉棕黄层来源的巨噬细胞中观察到类似变化。sEV含有miRNA-6516-5p,其抑制CD36并影响巨噬细胞脂质摄取。这些发现表明,sEV介导的miRNA作用导致CAD中保护性心包巨噬细胞减少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e336/11494395/4871d002e702/ga1.jpg

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