心包中的小细胞外囊泡调节冠状动脉疾病中的巨噬细胞免疫表型。

Small Extracellular Vesicles in the Pericardium Modulate Macrophage Immunophenotype in Coronary Artery Disease.

作者信息

Ben-Aicha Soumaya, Anwar Maryam, Vilahur Gemma, Martino Fabiana, Kyriazis Panagiotis G, de Winter Natasha, Punjabi Prakash P, Angelini Gianni D, Sattler Susanne, Emanueli Costanza

机构信息

National Heart and Lung Institute, Imperial College London, London, United Kingdom.

Cardiovascular Program-ICCC, IR-Hospital Santa Creu i Sant Pau, IIB-Sant Pau, Barcelona, Spain.

出版信息

JACC Basic Transl Sci. 2024 Jul 3;9(9):1057-1072. doi: 10.1016/j.jacbts.2024.05.003. eCollection 2024 Sep.

Coronary artery disease (CAD) is a major health issue. This study focused on pericardial macrophages and small extracellular vesicles (sEVs) in CAD. The macrophages in CAD patients showed reduced expression of protective markers and unchanged levels of proinflammatory receptors. Similar changes were observed in buffy-coat-derived macrophages when stimulated with CAD pericardial fluid-derived sEVs. The sEV contained miRNA-6516-5p, which inhibited CD36 and affected macrophage lipid uptake. These findings indicate that sEV-mediated miRNA actions contribute to the decrease in protective pericardial macrophages in CAD.