Amponsah A S, Lutterodt H E, Ankar-Brewoo G M, Ofosu I W
Department of Hospitality and Tourism, Sunyani Technical University, Sunyani, Ghana.
Food Systems Chemistry, Toxicology, and Risks Studies, Department of Food Science and Technology, College of Science, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Int J Food Sci. 2024 Oct 16;2024:5514988. doi: 10.1155/2024/5514988. eCollection 2024.
The polycyclic aromatic hydrocarbons (PAHs) congener concentrations and risk upon human exposure to smoked bushmeat products were analyzed. GC/MS MRM and QuEChERS methods were used for the analysis. This work has become necessary due to the need for more information concerning the quantitative determination of these compounds and their health risk assessment. The 16 PAH congeners identified were acenaphthylene (ACA), naphthalene (NAP), acenaphthene (ACE), fluorene (FLU), anthracene (ANT), phenanthrene (PHE), fluoranthene (FLT), pyrene (PYR), benzo[b]fluoranthene (BBF), benzo[k]fluoranthene (BKF), benzo[a]anthracene (BAA), chrysene (CHR), indeno(1,2,3-cd)pyrene (IND), dibenzo(a,h)anthracene (DAA), benzo(g,h,i)pyrene (BGP), and benzo[a]pyrene (BAP). At the 5% and 95% daily intake levels, BAP was at 3.34 and 17.39 g/kg(bw)/day, PAH4 was at 25.11 and 109.15 g/kg(bw)/day, and PAH8 was at 55.76 and 236.68 g/kg(bw)/day, respectively. BAP, PAH4, and PAH8 concentration exceeded the European Union limits, as BAP concentration was as low as 6.09 g/kg and as high as 34.19. The exposure values were significantly high. Specifically, the margin of exposure for BAP was as low as 2.09 × 10; for PAH4, it was 1.36 × 10; and for PAH8, it was 1.95 × 10 all at the 95% level. These figures are substantially lower than the benchmark of 10,000, indicating a higher ILTCR. Furthermore, the ILTCR ranged from a minimum of 47.77 to a maximum of 248.53 at the 5% and 95% levels, respectively. This study makes smoked bushmeat a public health concern because the higher figures obtained indicate higher carcinogenicity upon consumption.
分析了人类接触烟熏丛林肉产品时多环芳烃（PAHs）同系物的浓度及风险。采用气相色谱/质谱多反应监测（GC/MS MRM）和QuEChERS方法进行分析。由于需要更多关于这些化合物定量测定及其健康风险评估的信息，这项工作变得很有必要。鉴定出的16种PAH同系物为苊烯（ACA）、萘（NAP）、苊（ACE）、芴（FLU）、蒽（ANT）、菲（PHE）、荧蒽（FLT）、芘（PYR）、苯并[b]荧蒽（BBF）、苯并[k]荧蒽（BKF）、苯并[a]蒽（BAA）、 Chrysene（CHR）、茚并(1,2,3-cd)芘（IND）、二苯并(a,h)蒽（DAA）、苯并(g,h,i)芘（BGP）和苯并[a]芘（BAP）。在5%和95%的每日摄入量水平下，BAP分别为3.34和17.39 μg/kg(bw)/天，PAH4分别为25.11和109.15 μg/kg(bw)/天，PAH8分别为55.76和236.68 μg/kg(bw)/天。BAP、PAH4和PAH8的浓度超过了欧盟限值，因为BAP浓度低至6.09 μg/kg且高达34.19。暴露值显著偏高。具体而言，BAP的暴露边际低至2.09×10；PAH4为1.36×10；PAH8为1.95×10，均处于95%水平。这些数字远低于10000的基准，表明综合终生癌症风险（ILTCR）较高。此外，在5%和95%水平下，ILTCR分别最低为47.77，最高为248.53。这项研究使烟熏丛林肉成为一个公共卫生问题，因为获得的较高数字表明食用时致癌性更高。
