Cristol R, Debray J
J Mal Vasc. 1986;11(1):85-9.
The fingertip blood flow measured by mercury strain gauge plethysmography with venous occlusion, at 22 degrees C room temperature, had significantly lower mean values in 190 patients with Raynaud's phenomenon (55 men aged 49 yrs +/- 16, 135 women aged 48 yrs +/- 16) than in 40 age and sex matched controls: 18 ml/100 ml/minute +/- 14.6 versus 35 ml/100 ml/minute +/- 15 at level p less than 0.01. The mean fingertip blood flow was significantly lower (p less than 0.01) in 31 cases of scleroderma and 32 cases of pulpar necrosis (respectively 13 ml +/- 13 and 11 ml +/- 8) than in 55 cases of primary Raynaud's disease (no detectable etiology and normal capillaroscopy 5 years after onset) or in 34 cases of mild Raynaud's phenomenon (respectively 21.6 +/- 16 and 24.4 +/- 18). A warming test (both hands in water at 45 degrees C during 3 minutes) was performed in 50 cases with low basal fingertip blood flow. It induced a "normalized" flow in 22 cases (mostly primary or mild Raynaud), a partly improved flow in 20 cases (mostly secondary Raynaud) and no improvement in 8 cases (scleroderma). The warming test appears to be clinically useful to assess the vasospasm and the vasodilating capabilities.
在22摄氏度室温下,采用静脉阻断式汞应变仪体积描记法测量指尖血流量,结果显示,190例雷诺现象患者(55名男性,年龄49岁±16岁;135名女性,年龄48岁±16岁)的平均血流量显著低于40名年龄和性别匹配的对照组:分别为18毫升/100毫升/分钟±14.6与35毫升/100毫升/分钟±15,p值小于0.01。31例硬皮病患者和32例指端坏死患者的平均指尖血流量(分别为13毫升±13和11毫升±8)显著低于55例原发性雷诺病患者(发病5年后病因不明且毛细血管镜检查正常)或34例轻度雷诺现象患者(分别为21.6±16和24.4±18)(p值均小于0.01)。对50例基础指尖血流量较低的患者进行了一项升温试验(双手置于45摄氏度水中3分钟)。结果显示,22例患者(大多为原发性或轻度雷诺病)的血流量“恢复正常”,20例患者(大多为继发性雷诺病)的血流量部分改善,8例患者(硬皮病)的血流量无改善。升温试验在临床上似乎有助于评估血管痉挛和血管舒张能力。