European Molecular Biology Laboratory, Heidelberg, Germany.
Institut Pasteur, Paris, France.
Science. 2024 Oct 25;386(6720):446-453. doi: 10.1126/science.ado0251. Epub 2024 Oct 24.
Insect biomass is declining globally, likely driven by climate change and pesticide use, yet systematic studies on the effects of various chemicals remain limited. In this work, we used a chemical library of 1024 molecules-covering insecticides, herbicides, fungicides, and plant growth inhibitors-to assess the impact of sublethal pesticide doses on insects. In , 57% of chemicals affected larval behavior, and a higher proportion compromised long-term survivability. Exposure to sublethal doses also induced widespread changes in the phosphoproteome and changes in development and reproduction. The negative effects of agrochemicals were amplified when the temperature was increased. We observed similar behavioral changes across multiple insect species, including mosquitoes and butterflies. These findings suggest that widespread sublethal pesticide exposure can alter insect behavior and physiology, threatening long-term population survival.
昆虫生物量在全球范围内下降，可能是由气候变化和农药使用导致的，但对各种化学物质影响的系统研究仍然有限。在这项工作中，我们使用了一个包含 1024 种分子的化学文库——杀虫剂、除草剂、杀菌剂和植物生长抑制剂，来评估亚致死剂量的农药对昆虫的影响。在研究中，57%的化学物质影响幼虫的行为，而更高比例的化学物质则影响幼虫的长期生存能力。接触亚致死剂量也会诱导磷酸化蛋白质组的广泛变化，并影响发育和繁殖。当温度升高时，农用化学品的负面影响会加剧。我们在包括蚊子和蝴蝶在内的多种昆虫物种中观察到了类似的行为变化。这些发现表明，广泛的亚致死农药暴露会改变昆虫的行为和生理，威胁到长期的种群生存。
