2019-2021 年美国华盛顿州金县无家可归者收容所中柯萨奇病毒 A21 和肠道病毒 D68 的临床和基因组流行病学。
Clinical and Genomic Epidemiology of Coxsackievirus A21 and Enterovirus D68 in Homeless Shelters, King County, Washington, USA, 2019-2021.
出版信息
Emerg Infect Dis. 2024 Nov;30(11):2250-2260. doi: 10.3201/eid3011.240687.
Congregate homeless shelters are disproportionately affected by infectious disease outbreaks. We describe enterovirus epidemiology across 23 adult and family shelters in King County, Washington, USA, during October 2019-May 2021, by using repeated cross-sectional respiratory illness and environmental surveillance and viral genome sequencing. Among 3,281 participants >3 months of age, we identified coxsackievirus A21 (CVA21) in 39 adult residents (3.0% [95% CI 1.9%-4.8%] detection) across 7 shelters during October 2019-February 2020. We identified enterovirus D68 (EV-D68) in 5 adult residents in 2 shelters during October-November 2019. Of 812 environmental samples, 1 was EV-D68-positive and 5 were CVA21-positive. Other enteroviruses detected among residents, but not in environmental samples, included coxsackievirus A6/A4 in 3 children. No enteroviruses were detected during April 2020-May 2021. Phylogenetically clustered CVA21 and EV-D68 cases occurred in some shelters. Some shelters also hosted multiple CVA21 lineages.
收容所中的无家可归者受到传染病爆发的影响不成比例。我们通过对美国华盛顿州金县 23 个成人和家庭收容所的呼吸道疾病和环境监测以及病毒基因组测序，描述了 2019 年 10 月至 2021 年 5 月期间的肠病毒流行病学情况。在 3281 名年龄在 3 个月以上的参与者中，我们在 7 个收容所中发现了 39 名成年居民中的柯萨奇病毒 A21（CVA21）（3.0%[95%CI 1.9%-4.8%]检测率），检测时间为 2019 年 10 月至 2020 年 2 月。在 2019 年 10 月至 11 月期间，我们在 2 个收容所中发现了 5 名成年居民中的肠道病毒 D68（EV-D68）。在 812 个环境样本中，有 1 个样本为 EV-D68 阳性，5 个样本为 CVA21 阳性。在居民中检测到的其他肠道病毒，但在环境样本中未检测到，包括 3 名儿童中的柯萨奇病毒 A6/A4。2020 年 4 月至 2021 年 5 月期间未检测到肠道病毒。一些收容所中发生了具有亲缘关系的 CVA21 和 EV-D68 病例。一些收容所还收容了多个 CVA21 谱系。
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