Vanderhoff Anna C, Lanes Andrea, Herz-Roiphe Rachel, Mecklai Keizra, Camacho Oscar Leyva, Srouji Serene S, Easter Sarah Rae, Fox Janis, Rangel Erika L
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, and the Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts; the Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, and the Department of Obstetrics and Gynecology, New York University Langone Health, New York, New York; and the Division of Aerospace Medicine, San Antonio Military Medicine Center, Fort Sam Houston, Texas.
Obstet Gynecol. 2025 Jan 1;145(1):e24-e30. doi: 10.1097/AOG.0000000000005767. Epub 2024 Oct 24.
To evaluate outcomes of female physicians after assisted reproductive technology (ART).
We conducted a retrospective cohort study using data from 248 physician patients and 3,470 nonphysician patients who underwent a total of 10,095 fresh or frozen ART cycles at a single academic center in an insurance-mandated state between January 2015 and March 2022. The primary outcome was live-birth rate. The secondary outcomes were implantation rate, early pregnancy loss rate, and time to pregnancy. Models were adjusted for confounders where appropriate.
Both groups were similar in age (mean physician age 36.29 years; mean nonphysician age 35.96 years, P =.35). Physicians had lower body mass index (BMI) (mean physician BMI 23.51, mean nonphysician BMI 26.37, P <.01), and a higher proportion were diagnosed with unexplained infertility (physician 33.9%, nonphysician 25.9%, P <.01) and used preimplantation genetic testing for aneuploidy (physician 21.5%, nonphysician 12.7%). Physicians and nonphysicians had similar live-birth rates (physician 39.3%, nonphysician 38.2%; adjusted relative risk [aRR] 1.01 95% CI, 0.91-1.13), implantation rates (physician 34.7%, nonphysician 33.7%; relative risk 1.03 95% CI, 0.94-1.14), and early pregnancy loss rates (physician 21.9%, nonphysician 19.8%; aRR 1.18 95% CI, 0.99-1.41) per transfer. Physicians had a shorter time from initial ART cycle to pregnancy (physician 21.82 weeks, nonphysician 25.16 weeks; aRR 0.86, 95% CI, 0.83-0.89).
There was no difference between female physicians and nonphysicians in assisted reproduction cycle outcomes. Physicians become pregnant slightly faster than nonphysicians.
评估辅助生殖技术（ART）后女性医生的治疗结局。
我们进行了一项回顾性队列研究，使用了2015年1月至2022年3月期间在一个保险强制要求的州的单一学术中心接受总共10,095个新鲜或冷冻ART周期的248名医生患者和3,470名非医生患者的数据。主要结局是活产率。次要结局是着床率、早期妊娠丢失率和妊娠时间。在适当情况下对模型进行混杂因素调整。
两组年龄相似（医生平均年龄36.29岁；非医生平均年龄35.96岁，P = 0.35）。医生的体重指数（BMI）较低（医生平均BMI 23.51，非医生平均BMI 26.37，P < 0.01），被诊断为不明原因不孕症的比例较高（医生33.9%，非医生25.9%，P < 0.01），并且使用非整倍体植入前基因检测的比例较高（医生21.5%，非医生12.7%）。医生和非医生的活产率相似（医生39.3%，非医生38.2%；调整后相对风险[aRR] 1.01，95% CI，0.91 - 1.13），着床率相似（医生34.7%，非医生33.7%；相对风险1.03，95% CI，0.94 - 1.14），每次移植的早期妊娠丢失率相似（医生21.9%，非医生19.8%；aRR 1.18，95% CI，0.99 - 1.41）。医生从初始ART周期到妊娠的时间较短（医生21.82周，非医生25.16周；aRR 0.86，95% CI，0.83 - 0.89）。
女性医生和非医生在辅助生殖周期结局方面没有差异。医生怀孕的速度比非医生略快。
