Zhou Zhengqing, Li Chaofei, Zeng Yue, Huang Tianyue, Jiang Xuewen, Yu Deng-Guang, Wang Ke
School of Materials and Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Department of General Surgery, RuiJin Hospital Lu Wan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Int J Biol Macromol. 2024 Dec;282(Pt 2):136688. doi: 10.1016/j.ijbiomac.2024.136688. Epub 2024 Oct 22.
Diabetic wounds present a chronic challenge in effective treatment. Natural polymer nanofiber dressings have emerged as a promising solution due to their impressive biocompatibility, biodegradability, safety, high specific surface area, and resemblance to the extracellular matrix. These qualities make them ideal materials with excellent biological properties and cost-effectiveness. Additionally, they can effectively deliver therapeutic agents, enabling diverse treatment effects. This review offers a comprehensive overview of natural polymer-based nanofibers in diabetic wound dressings. It examines the characteristics and challenges associated with diabetic wounds and the role of natural polymers in facilitating wound healing. The review highlights the preparation, mechanism, and applications of various functional dressings composed of natural polymer nanofibers. Furthermore, it addresses the main challenges and future directions in utilizing natural polymer nanofibers for diabetic wound treatment, providing valuable insights into effective wound management for diabetic patients.
糖尿病伤口的有效治疗是一项长期面临的挑战。天然聚合物纳米纤维敷料因其出色的生物相容性、生物降解性、安全性、高比表面积以及与细胞外基质的相似性，已成为一种有前景的解决方案。这些特性使其成为具有优异生物学特性和成本效益的理想材料。此外，它们能够有效地递送治疗剂，从而实现多种治疗效果。本综述全面概述了用于糖尿病伤口敷料的基于天然聚合物的纳米纤维。它研究了与糖尿病伤口相关的特征和挑战，以及天然聚合物在促进伤口愈合中的作用。该综述强调了由天然聚合物纳米纤维组成的各种功能性敷料的制备、作用机制和应用。此外，它还探讨了利用天然聚合物纳米纤维治疗糖尿病伤口的主要挑战和未来方向，为糖尿病患者的有效伤口管理提供了有价值的见解。
